从黄花杜鹃花朵中提取的具有对草地贪夜蛾细胞系细胞毒性活性的木藜芦烷二萜类化合物。

Grayanane diterpenoids from the flowers of Rhododendron molle with cytotoxic activity against a Spodoptera frugiperda cell line.

作者信息

Zhong Guohua, Hu Meiying, Wei Xiaoyi, Weng Qunfang, Xie Jianjun, Liu Jingxiang, Wang Wenxiang

机构信息

Laboratory of Insect Toxicology, South China Agricultural University and Key Laboratory of Pesticides and Chemical Biology, Ministry of Education of the People's Republic of China, Guangzhou.

出版信息

J Nat Prod. 2005 Jun;68(6):924-6. doi: 10.1021/np049645t.

DOI:10.1021/np049645t

PMID:15974620

Abstract

Two new grayanane diterpenoids, rhodomolins A (1) and B (2), together with two known diterpenoids, rhodomolleins I and rhodojaponin III, were isolated from the flowers of Rhododendron molle. The structures of 1 and 2 were elucidated on the basis of interpretation of spectroscopic data. All compounds were evaluated for cytotoxic activity against the Spodoptera frugiperda cell line Sf-9 and gave IC(50) values in the range 12-80 microg/mL.

摘要

从黄花杜鹃的花中分离出两种新的木藜芦烷二萜类化合物，即闹羊花素A（1）和闹羊花素B（2），以及两种已知的二萜类化合物，闹羊花毒素I和闹羊花毒素III。通过光谱数据解析确定了1和2的结构。对所有化合物进行了抗草地贪夜蛾细胞系Sf-9的细胞毒性活性评估，其半数抑制浓度（IC50）值在12-80μg/mL范围内。