Isodon eriocalyx 中双萜类化合物的结构和细胞毒性。

Structure and cytotoxicity of diterpenoids from Isodon eriocalyx.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.

出版信息

J Nat Prod. 2010 Nov 29;73(11):1803-9. doi: 10.1021/np1004328. Epub 2010 Oct 15.

DOI:10.1021/np1004328

PMID:20949916

Abstract

A new ent-atisanoid, eriocatisin A (1), six new ent-abietanoids, eriocasins B-E (2-4, 7), 3-acetyleriocasin C (5), and 3β-acetoxyeriocasin D (6), and seven new ent-kauranoids, maoesins A-F (8, 10-14) and 3α-acetoxy-maoesin A (9), together with 21 known compounds, were isolated from the aerial parts of Isodon eriocalyx. The structures of 1-14 were determined by spectroscopic data interpretation. All compounds isolated were evaluated for their in vitro growth inhibitory activity against the HT-29, BEL-7402, and SK-OV-3 human cancer cell lines. Compounds 17, 18, and 20 showed inhibitory effects for all three tumor cell lines used, with IC(50) values in the range 2.1-7.3 μM.

摘要

一种新的 ent-atisanoid，eriocatisin A（1），六个新的 ent-abietanoids，eriocasins B-E（2-4，7），3-acetyleriocasin C（5）和 3β-acetoxyeriocasin D（6），以及七个新的 ent-kauranoids，maoesins A-F（8，10-14）和 3α-acetoxy-maoesin A（9），与 21 种已知化合物一起，从 Isodon eriocalyx 的地上部分分离得到。通过光谱数据分析确定了 1-14 的结构。所有分离得到的化合物均对 HT-29、BEL-7402 和 SK-OV-3 人癌细胞系进行了体外生长抑制活性评估。化合物 17、18 和 20 对所有三种肿瘤细胞系均显示出抑制作用，IC（50）值在 2.1-7.3μM 范围内。