Alderton M R, Borland R, Coloe P J
Department of Applied Biology, Victoria University of Technology, Melbourne, Australia.
J Comp Pathol. 1992 Feb;106(2):159-67. doi: 10.1016/0021-9975(92)90045-v.
A campylobacter-like bacterium, isolated from the terminal ileum of a pig with porcine proliferative enteritis (PPE), was used to initiate PPE in healthy crossbred pigs. Post-mortem examinations of pigs infected orally with the bacterium revealed thickening of the terminal ileum, haemorrhage within the ileum, degeneration of ileal villi and large quantities of bile and mucous in the ileal contents. Histopathological examination revealed that the terminal ileum, ileo-caecal valve and caecum from infected pigs had partial or total loss of mucous membrane, hyperplasia of the crypt and glandular epithelial cells, campylobacter-like organisms in and around the Peyers' patches and lymphoid aggregates in the mucosa. The causative organism was re-isolated from the intestinal specimens of infected animals post-mortem. In control animals, kept under the same conditions, no evidence of abnormality was observed in the terminal ileum, ileo-caecal valve or caecum.
从患有猪增生性肠炎（PPE）的猪的回肠末端分离出一种弯曲杆菌样细菌，用于使健康的杂种猪感染PPE。对经口感染该细菌的猪进行的尸检显示，回肠末端增厚、回肠内出血、回肠绒毛变性以及回肠内容物中有大量胆汁和黏液。组织病理学检查显示，感染猪的回肠末端、回盲瓣和盲肠有部分或全部黏膜丧失、隐窝和腺上皮细胞增生、派伊尔结及其周围有弯曲杆菌样生物体以及黏膜中的淋巴样聚集物。在尸检时从感染动物的肠道标本中再次分离出致病生物体。在相同条件下饲养的对照动物中，未观察到回肠末端、回盲瓣或盲肠有异常迹象。
