Munro Sean
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
Curr Opin Cell Biol. 2005 Aug;17(4):395-401. doi: 10.1016/j.ceb.2005.06.013.
The Golgi apparatus is a stack of compartments that serves as a central junction for membrane traffic, with carriers moving through the stack as well as arriving from, and departing toward, many other destinations in the cell. This requires that the different compartments in the Golgi recruit from the cytosol a distinct set of proteins to mediate accurate membrane traffic. This recruitment appears to reflect recognition of small GTPases of the Rab and Arf family, or of lipid species such as PtdIns(4)P and diacylglycerol, which provide a unique "identity" for each compartment. Recent work is starting to reveal the mechanisms by which these labile landmarks are generated in a spatially restricted manner on specific parts of the Golgi.
高尔基体是一堆隔室，作为膜运输的中心枢纽，载体在隔室堆栈中移动，同时从细胞内的许多其他目的地抵达并离开。这就要求高尔基体中的不同隔室从细胞质中招募一组独特的蛋白质，以介导精确的膜运输。这种招募似乎反映了对Rab和Arf家族的小GTP酶，或脂质种类如磷脂酰肌醇-4-磷酸（PtdIns(4)P）和二酰基甘油的识别，它们为每个隔室提供了独特的“身份”。最近的研究开始揭示这些不稳定标记物在高尔基体特定部位以空间受限方式产生的机制。
