Perret Emilie, Lakkaraju Aparna, Deborde Sylvie, Schreiner Ryan, Rodriguez-Boulan Enrique
Margaret Dyson Vision Research Institute, LC-300, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.
Curr Opin Cell Biol. 2005 Aug;17(4):423-34. doi: 10.1016/j.ceb.2005.06.008.
The cell biologist's insight into endosomal diversity, in terms of both form and function, has increased dramatically in the past few years. This understanding has been promoted by the availability of powerful new techniques that allow imaging of both cargo and machinery in the endocytic process in real time, and by our ability to inhibit components of this machinery by RNA interference. The emerging picture from these studies is of a highly complex, dynamic and adaptable endosomal system that interacts at various points with the secretory system of the cell.
在过去几年里，细胞生物学家对内涵体在形态和功能方面多样性的认识有了显著提高。强大的新技术的出现推动了这种认识，这些新技术能够实时成像内吞过程中的货物和机制，同时我们也能够通过RNA干扰抑制该机制的组成部分。这些研究呈现出的新情况是，内涵体系统高度复杂、动态且具有适应性，它在多个点与细胞的分泌系统相互作用。
