Kasahara Ken, Nomura Shinkichi, Matsuura Hideyuki, Yamasaki Masahiro, Yamato Osamu, Maede Yoshimitsu, Katakura Ken, Suzuki Mamoru, Yoshihara Teruhiko
Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan.
Planta Med. 2005 May;71(5):482-4. doi: 10.1055/s-2005-871216.
Anti-babesial activity was confirmed in an extract of the bark of Curcuma zedoaria. The active ingredients were isolated, and their chemical structures were determined to be zedoalactones A, B, and C based on spectral data. Zedoalactone C is a hitherto unreported compound. The IC50 vales of these active compounds against Babesia gibsoni were compared with a standard drug, diminazene aceturate. The IC50 value of diminazene aceturate was 0.6 microg/mL, while those of zedoalactones A, B, and C were 16.5, 1.6 and 4.2 microg/mL, respectively.
