Palomar Rosa, Fernández-Fresnedo Gema, Domínguez-Diez Agustín, López-Deogracias Maite, Olmedo Francisco, Martín de Francisco Angel L, Sanz de Castro Saturnino, Casado Martín Fernando, Gómez-Fleitas Manuel, Arias Manuel, Fernández-Escalante Carlos
Department of Nephrology, Hospital Marqués de Valdecilla, University of Cantabria, 39008 Santander, Spain.
Obes Surg. 2005 Jun-Jul;15(6):794-8. doi: 10.1381/0960892054222687.
Obesity is associated with increased prevalence of cardiovascular risk factors. Biliopancreatic diversion (BPD) for morbid obesity has been reported to produce anemia and malnutrition in short-term follow-up. The aim of our study was to analyze the effect of weight reduction on cardiovascular profile, renal function and nutritional status.
35 morbidly obese patients underwent BPD. We analyzed the presence of cardiovascular risk factors, renal status, proteinuria and nutritional status before and 1 year after BPD.
Excess weight loss was 67% at 1 year after BPD. All cardiovascular risk factors (hypertension, diabetes, hyperlipidemia) improved during follow-up. We could not find any relevant signs of malnutrition in the patients. Microalbuminuria decreased and proteinuria disappeared after weight loss. We observed less urinary calcium and citrate excretion, with an increase in oxaluria, but these changes did not increase the incidence of renal stones.
BPD was followed by improved cardiovascular profile and a lower pro-inflammatory state. BPD did not produce significant malnutrition, anemia or renal stone disease.
肥胖与心血管危险因素的患病率增加有关。据报道，用于治疗病态肥胖的胆胰分流术（BPD）在短期随访中会导致贫血和营养不良。我们研究的目的是分析体重减轻对心血管状况、肾功能和营养状况的影响。
35例病态肥胖患者接受了BPD。我们分析了BPD术前及术后1年心血管危险因素、肾脏状况、蛋白尿和营养状况的情况。
BPD术后1年超重减轻了67%。随访期间所有心血管危险因素（高血压、糖尿病、高脂血症）均有所改善。我们在患者中未发现任何相关的营养不良迹象。体重减轻后微量白蛋白尿减少，蛋白尿消失。我们观察到尿钙和枸橼酸盐排泄减少，草酸尿增加，但这些变化并未增加肾结石的发生率。
BPD术后心血管状况改善，促炎状态降低。BPD未导致明显的营养不良、贫血或肾结石疾病。
