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宽吻海豚（瓶鼻海豚）初乳中一种独特唾液酸四糖的出现。

Occurrence of a unique sialyl tetrasaccharide in colostrum of a bottlenose dolphin (Tursiops truncatus).

作者信息

Uemura Yusuke, Asakuma Sadaki, Nakamura Tadashi, Arai Ikichi, Taki Michihiro, Urashima Tadasu

机构信息

Department of Bioresource Chemistry, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080-8555, Japan.

出版信息

Biochim Biophys Acta. 2005 Oct 10;1725(3):290-7. doi: 10.1016/j.bbagen.2005.05.011. Epub 2005 May 31.

DOI:10.1016/j.bbagen.2005.05.011
PMID:15978735
Abstract

Crude oligosaccharides were recovered from bottlenose dolphin (Tursiops truncatus) colostrum after chloroform/methanol extraction of lipids and protein precipitation, and purified using gel filtration, anion exchange chromatography and high performance liquid chromatography (HPLC). Their chemical structures characterized by NMR spectroscopy were as follows: GalNAc(beta1-4)[Neu5Ac(alpha2-3)]Gal(beta1-4)Glc, Neu5Ac(alpha2-3)Gal(beta1-4)Glc, Neu5Ac(alpha2-6)Gal(beta1-4)Glc and Gal(alpha1-4)Gal(beta1-4)Glc. The monosialyltetrasaccharide and neutral trisaccharide have not previously been found as free forms in any natural sources including milk or colostrum, although these structures have been found in the carbohydrate units of glycosphingolipids GM2 and Gb3.

摘要

在对脂质进行氯仿/甲醇萃取以及蛋白质沉淀后，从宽吻海豚（Tursiops truncatus）初乳中回收粗制低聚糖，并通过凝胶过滤、阴离子交换色谱和高效液相色谱（HPLC）进行纯化。通过核磁共振光谱表征的它们的化学结构如下：GalNAc(β1-4)[Neu5Ac(α2-3)]Gal(β1-4)Glc、Neu5Ac(α2-3)Gal(β1-4)Glc、Neu5Ac(α2-6)Gal(β1-4)Glc和Gal(α1-4)Gal(β1-4)Glc。单唾液酸四糖和中性三糖以前在包括牛奶或初乳在内的任何天然来源中都未以游离形式被发现，尽管这些结构已在糖鞘脂GM2和Gb3的碳水化合物单元中被发现。

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