Hill Ashleigh, McFarlane Suzanne, Johnston Patrick G, Waugh David J J
Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast City Hospital, Lisburn Road, Belfast, Northern Ireland, BT9 7AB, UK.
Cancer Lett. 2006 Jun 8;237(1):1-9. doi: 10.1016/j.canlet.2005.05.006. Epub 2005 Jun 27.
The hyaluronan (HA) receptor CD44 has a well documented role in tumour metastasis. This review focuses on the potential significance of CD44 expression and function in regulating the metastasis of both haematological malignancies and solid tumours to the bone. Specifically, the review will discuss the evidence that HA-CD44 interactions facilitate the arrest of circulating malignant cells upon the bone marrow endothelial cells and discuss data that suggests CD44 may orchestrate the ability of tumour cells to regulate the modification of the bone matrix and support its colonisation by malignant cells.
透明质酸（HA）受体CD44在肿瘤转移中具有充分记载的作用。本综述聚焦于CD44表达和功能在调节血液系统恶性肿瘤及实体瘤向骨转移方面的潜在意义。具体而言，本综述将讨论透明质酸与CD44相互作用促进循环恶性细胞在骨髓内皮细胞上滞留的证据，并探讨表明CD44可能协调肿瘤细胞调节骨基质修饰及支持恶性细胞在骨内定植能力的数据。
