Hall Barry G, Salipante Stephen J, Barlow Miriam
Biology Department, Hutchison Hall, University of Rochester, Rochester, NY 14627-0211, USA.
J Mol Evol. 2003 Sep;57(3):249-54. doi: 10.1007/s00239-003-2471-0.
The Ambler Class B metallo-beta-lactamases fall into two distinct phylogenetic groups based on the observation that there is no significant sequence homology between the sequences of members of different groups. Structural alignments confirm that those groups are no more closely related to each other than are the three classes of serine beta-lactamases, Classes A, C, and D. We present phylogenies of these two groups and suggest a new classification scheme for the beta-lactamases.
基于不同组的成员序列之间不存在显著序列同源性这一观察结果，安布勒B类金属β-内酰胺酶可分为两个不同的系统发育组。结构比对证实，这些组之间的亲缘关系并不比丝氨酸β-内酰胺酶的A、C和D三类更为密切。我们展示了这两个组的系统发育情况，并提出了一种新的β-内酰胺酶分类方案。
