Benson Dennis A, Karsch-Mizrachi Ilene, Lipman David J, Ostell James, Wheeler David L
Department of Health and Human Services, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
Nucleic Acids Res. 2005 Jan 1;33(Database issue):D34-8. doi: 10.1093/nar/gki063.
GenBank is a comprehensive database that contains publicly available DNA sequences for more than 165,000 named organisms, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects. Most submissions are made using the web-based BankIt or standalone Sequin programs and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the EMBL Data Library in the UK and the DNA Data Bank of Japan helps to ensure worldwide coverage. GenBank is accessible through NCBI's retrieval system, Entrez, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, go to the NCBI Homepage at http://www.ncbi.nlm.nih.gov.
GenBank是一个综合性数据库,包含超过165,000种命名生物的公开可用DNA序列,主要通过各个实验室的提交以及大规模测序项目的批量提交获得。大多数提交是使用基于网络的BankIt程序或独立的Sequin程序进行的,GenBank工作人员在收到提交后会分配登录号。与英国的EMBL数据库和日本的DNA数据库进行每日数据交换有助于确保全球范围的覆盖。GenBank可通过NCBI的检索系统Entrez访问,该系统整合了来自主要DNA和蛋白质序列数据库的数据,以及分类学、基因组、图谱、蛋白质结构和结构域信息,还通过PubMed整合了生物医学期刊文献。BLAST可对GenBank和其他序列数据库进行序列相似性搜索。GenBank数据库每两个月进行一次完整发布,并通过FTP进行每日更新。要访问GenBank及其相关的检索和分析服务,请访问NCBI主页:http://www.ncbi.nlm.nih.gov。