Tedaldi E M, Chen L, Markowitz N, Kelly L, Abrams D
University School of Medicine, Temple General Internal Medicine, 1316 W. Ontario Street, Philadelphia, PA 19140, USA.
J Viral Hepat. 2005 Jul;12(4):414-20. doi: 10.1111/j.1365-2893.2005.00610.x.
The effect of interleukin-2 (IL-2) on the plasma levels of hepatitis C RNA (HCV-RNA) has varied in published reports. We measured the impact of IL-2 on plasma HCV RNA levels in 54 human immunodeficiency virus (HIV)/HCV coinfected patients enrolled in a randomized trial of 512 participants designed to compare the virologic and immunologic effects of cycled IL-2 plus antiretroviral therapy (ART) vs ART alone in the treatment of HIV in patients with CD4 cell counts > or =300 cells/mm(3). The mean decreases in average HCV RNA levels (copies/mL, log (10)) were 0.28 log in the IL-2 group (n = 26) and 0.04 log in the ART alone group (n = 28) at 12 months (P = 0.18). The changes in HCV RNA level were not associated with baseline or nadir CD4 cell counts, baseline aspartate aminotransferanse, CD4 cell response to IL-2, or changes in plasma HIV RNA values. Compared with those participants who only had HIV, the HIV/HCV co-infected patients did not have a significantly different CD4 cell response to IL-2 therapy. Intermittent IL-2 therapy does not produce a significant sustained decrease in plasma HCV RNA levels among patients co-infected with HIV/HCV who are on highly active ART.
白细胞介素-2（IL-2）对丙型肝炎病毒RNA（HCV-RNA）血浆水平的影响在已发表的报告中各不相同。我们在一项有512名参与者的随机试验中，测量了IL-2对54例人类免疫缺陷病毒（HIV）/HCV合并感染患者血浆HCV RNA水平的影响，该试验旨在比较循环IL-2联合抗逆转录病毒疗法（ART）与单纯ART在CD4细胞计数≥300个细胞/mm³的HIV患者治疗中的病毒学和免疫学效果。在12个月时，IL-2组（n = 26）平均HCV RNA水平（拷贝/mL，log(10)）的平均下降为0.28 log，单纯ART组（n = 28）为0.04 log（P = 0.18）。HCV RNA水平的变化与基线或最低点CD4细胞计数、基线天冬氨酸转氨酶、CD4细胞对IL-2的反应或血浆HIV RNA值的变化无关。与仅感染HIV的参与者相比，HIV/HCV合并感染患者对IL-2治疗的CD4细胞反应没有显著差异。在接受高效抗逆转录病毒治疗的HIV/HCV合并感染患者中，间歇性IL-2治疗不会使血浆HCV RNA水平产生显著的持续下降。
