在过去20年里，日本戊型肝炎病毒的年龄特异性抗体一直保持稳定。
Age-specific antibody to hepatitis E virus has remained constant during the past 20 years in Japan.
作者信息
Tanaka E, Matsumoto A, Takeda N, Li T-C, Umemura T, Yoshizawa K, Miyakawa Y, Miyamura T, Kiyosawa K
机构信息
Department of Medicine, Shinshu University School of Medicine, Asahi, Matsumoto, Japan.
出版信息
J Viral Hepat. 2005 Jul;12(4):439-42. doi: 10.1111/j.1365-2893.2005.00616.x.
We investigated the presence of antibodies to hepatitis E virus (anti-HEV) and hepatitis A virus (anti-HAV) by enzyme immunoassays in sera from 1015 individuals collected in 1974, 1984 and 1994. Age-specific profiles of anti-HEV remained unchanged with a peak at 40-49 years, while those of anti-HAV started to increase in individuals aged 20-29 years in 1974, 30-39 years in 1984 and 40-49 years in 1994. These results suggest that a silent HEV infection has been taking place in the last 20 years or so in Japan, while HAV infection has been terminated at least since 1974.
我们通过酶免疫测定法，对1974年、1984年和1994年采集的1015名个体血清中的戊型肝炎病毒抗体（抗 - HEV）和甲型肝炎病毒抗体（抗 - HAV）进行了调查。抗 - HEV的年龄特异性分布保持不变，在40 - 49岁达到峰值，而抗 - HAV的年龄特异性分布在1974年20 - 29岁的个体中开始上升，1984年在30 - 39岁个体中开始上升，1994年在40 - 49岁个体中开始上升。这些结果表明，在过去约20年里日本一直在发生戊型肝炎病毒的隐性感染，而甲型肝炎病毒感染至少自1974年以来已被阻断。
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