γ-促黑素肽在肾上腺类固醇生成调节中的作用。

Role of gamma-MSH peptides in the regulation of adrenal steroidogenesis.

作者信息

Harmer Stephen C, Bicknell Andrew B

机构信息

School of Animal and Microbial Sciences, The University of Reading, Whiteknights, P.O. Box 228, Reading, Berkshire RG6 6AJ, UK.

出版信息

Peptides. 2005 Oct;26(10):1944-51. doi: 10.1016/j.peptides.2004.11.028.

DOI:10.1016/j.peptides.2004.11.028

PMID:15985307

Abstract

Alpha-, beta- and gamma-melanocyte stimulating hormones (MSHs) are peptides derived from the ACTH precursor, pro-opiomelanocortin. All three peptides have been highly conserved throughout evolution but their exact biological function in mammals is still largely obscure. In recent years, there has been a surge of interest in alpha-MSH and its role in the regulation of feeding. Gamma-MSH by contrast has been shown to be involved in the regulation of adrenal steroidogenesis and also has effects on the cardiovascular and renal systems. This review will provide an overview of the role that gamma-MSH peptides play in the regulation of adrenal steroidogenesis.

摘要

α-、β-和γ-黑素细胞刺激素（MSHs）是源自促肾上腺皮质激素前体——阿黑皮素原的肽类。这三种肽在整个进化过程中高度保守，但它们在哺乳动物体内的确切生物学功能仍大多不明。近年来，人们对α-MSH及其在进食调节中的作用兴趣激增。相比之下，γ-MSH已被证明参与肾上腺类固醇生成的调节，并且对心血管和肾脏系统也有影响。本综述将概述γ-MSH肽在肾上腺类固醇生成调节中所起的作用。