Pro-opiocortin: the multiple adrenal hormone precursor. Review.

Corticotropin (ACTH) is biosynthesized in the human pituitary gland as a long polypeptide precursor (pro-opiocortin) of some 240 residues. When ACTH is secreted in response to stress, the peptides derived from the rest of this precursor, pro-gamma-melanotropin (gamma-MSH) and beta-lipotropin (beta-LPH), are also secreted (Fig. 1). This article will describe the search for a biological significance for this phenomenon.