Coordination of Prevention and Surveillance, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.
Environmental Mutagenesis Laboratory, Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro, Brazil.
PLoS One. 2024 Feb 26;19(2):e0297140. doi: 10.1371/journal.pone.0297140. eCollection 2024.
Non-Hodgkin's Lymphoma (NHL) is a malignancy of the lymphoid lineage of the hematopoietic system has worldwide, especially in developed countries. Better diagnostic and recording techniques, longer life expectancy, and greater exposure to risk factors are hypotheses for this growing incidence curve. Occupational exposures to chemical, biological, and physical agents have also been associated with NHL development, but the results are still controversial. We have investigated the occupational and lifestyle case-control study design with 214 adult patients and 452 population controls. Socio-demographic, clinical, and occupational exposure data were obtained through individual interviews with a standardized questionnaire. Clinical, laboratory, and histopathological data were obtained through medical records. Risk of NHL (any subtype), B-cell lymphoma, DLBCL, Follicular lymphoma and T-cell lymphoma was elevated among the those who had ever been exposed to any solvents, hydrocarbon solvents, pesticides, meat and meat products, and sunlight and tended to increase by years of exposure. A significant upward trend with years of exposure was detected for any solvents and hydrocarbon solvents (NHL (any subtype) p-value for trend<0.001), B-cell lymphoma (p-value for trend<0.001), and T-cell lymphoma (p-value for trend<0.023), pesticides (NHL (any subtype), p for trend<0.001) and T-cell lymphoma (p for trend<0.002), meat and meat products (NHL (any subtype) (p for trend<0.001) and DLBCL (p for trend<0.001), and sunlight (B-cell lymphoma (p for trend<0.001). The results of this study agree line with other international studies, can be extrapolated to other countries that have the same socio-demographic and occupational characteristics as Brazil and support strategies for surveillance and control of work-related cancer.
非霍奇金淋巴瘤（NHL）是一种起源于造血系统淋巴谱系的恶性肿瘤，在全球范围内均有发病，尤其在发达国家。更好的诊断和记录技术、更长的预期寿命以及更多地接触危险因素，这些都是发病率曲线不断上升的假设。职业暴露于化学、生物和物理因素也与 NHL 的发生有关，但结果仍存在争议。我们采用病例对照研究设计，对 214 名成年患者和 452 名人群对照进行了职业和生活方式方面的研究。通过使用标准化问卷进行个体访谈，获得了社会人口统计学、临床和职业暴露数据。通过病历获得了临床、实验室和组织病理学数据。NHL（任何亚型）、B 细胞淋巴瘤、弥漫性大 B 细胞淋巴瘤、滤泡性淋巴瘤和 T 细胞淋巴瘤的发病风险在曾接触过任何溶剂、碳氢化合物溶剂、杀虫剂、肉类和肉类产品以及阳光的人群中升高，且风险随着暴露年限的增加而增加。任何溶剂和碳氢化合物溶剂（NHL（任何亚型）趋势检验 P 值<0.001）、B 细胞淋巴瘤（趋势检验 P 值<0.001）和 T 细胞淋巴瘤（趋势检验 P 值<0.023）、杀虫剂（NHL（任何亚型），趋势检验 P 值<0.001）和 T 细胞淋巴瘤（趋势检验 P 值<0.002）、肉类和肉类产品（NHL（任何亚型）（趋势检验 P 值<0.001）和弥漫性大 B 细胞淋巴瘤（趋势检验 P 值<0.001）以及阳光（B 细胞淋巴瘤（趋势检验 P 值<0.001）暴露年限与发病风险之间存在显著的上升趋势。本研究结果与其他国际研究一致，可以外推到与巴西具有相同社会人口统计学和职业特征的其他国家，并支持针对与工作相关癌症的监测和控制的策略。
