Breitschwerdt Edward B, DebRoy Chitrita, Mexas Angela M, Brown Talmage T, Remick Amera K
Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
J Am Vet Med Assoc. 2005 Jun 15;226(12):2016-9, 2001. doi: 10.2460/javma.2005.226.2016.
A 7-month-old sexually intact male Cocker Spaniel was admitted to the North Carolina State University Veterinary Teaching Hospital for evaluation of lethargy, panting, and excessive salivation that had become progressively severe during a 5-hour period. Despite intensive medical care, the dog died within the first 24 hours of hospitalization, and death was attributed to acute, severe, necrotizing pneumonia. Lung tissue collected at necropsy by use of swabs was cultured and yielded an isolate of Escherichia coli; because of the rapid progression of illness in an otherwise healthy dog, the isolate underwent virulence typing and was determined to be a necrotoxigenic E. coli. Necrotoxigenic E. coli produce a toxin called cytotoxic necrotizing factor and are known to be involved in extraintestinal infections, including urinary tract infection, in humans and animals. Virulence typing of E. coli isolates from dogs with peracute pneumonia is recommended to further characterize the epidemiologic characteristics and public health importance of necrotoxigenic E. coli.
一只7个月大、未绝育的雄性可卡犬被送往北卡罗来纳州立大学兽医教学医院，以评估其嗜睡、喘气和流涎过多的症状，这些症状在5小时内逐渐加重。尽管进行了强化医疗护理，但这只狗在住院的头24小时内死亡，死亡原因是急性、严重、坏死性肺炎。尸检时用拭子采集的肺组织进行培养，分离出一株大肠杆菌；由于这只原本健康的狗病情发展迅速，对分离株进行了毒力分型，确定为产坏死毒素大肠杆菌。产坏死毒素大肠杆菌产生一种名为细胞毒性坏死因子的毒素，已知其与人和动物的肠道外感染有关，包括尿路感染。建议对患有超急性肺炎的犬只分离出的大肠杆菌进行毒力分型，以进一步了解产坏死毒素大肠杆菌的流行病学特征和公共卫生重要性。
