Sura R, Van Kruiningen H J, DebRoy C, Hinckley L S, Greenberg K J, Gordon Z, French R A
Connecticut Veterinary Medical Diagnostic Laboratory, Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT 06269, USA.
Zoonoses Public Health. 2007;54(8):307-13. doi: 10.1111/j.1863-2378.2007.01067.x.
Extraintestinal pathogenic Escherichia coli (ExPEC) are pathogens involved in several disease conditions, ranging from urinary tract infection to meningitis in humans and animals. They comprise epidemiologically and phylogenetically distinct strains, affecting most species and involving any organ or anatomical site. Here, we report fatal cases of necrotizing pneumonia in cats. Over a 1-week period, 13 cats from an animal shelter in Stamford, Connecticut were presented for necropsy. All had a clinical history of acute respiratory disease. The gross and microscopic findings for all the cats were consistent. Escherichia coli was uniformly isolated from the lungs of all the tested cats. All the isolates were haemolytic, genetically related as determined by enterobacterial repetitive intergenic consensus PCR, and harboured genes encoding for cytotoxic necrotizing factor-1 and fimbriae and adhesions that are characteristic of ExPEC, implying a point source clonal outbreak. As cats are common household pets, this report raises concerns regarding zoonotic potential (in either direction) for these ExPEC strains.
肠外致病性大肠杆菌（ExPEC）是涉及多种疾病的病原体，范围从人类和动物的尿路感染到脑膜炎。它们包括在流行病学和系统发育上不同的菌株，影响大多数物种，并涉及任何器官或解剖部位。在此，我们报告猫坏死性肺炎的致死病例。在1周时间内，来自康涅狄格州斯坦福德市一家动物收容所的13只猫被送去进行尸检。所有猫都有急性呼吸道疾病的临床病史。所有猫的大体和微观检查结果一致。在所有接受检测的猫的肺中均一致分离出大肠杆菌。所有分离株均具有溶血特性，通过肠杆菌重复基因间共识PCR确定它们在基因上相关，并且携带编码细胞毒性坏死因子-1以及ExPEC特征性菌毛和黏附素的基因，这意味着是由单一污染源引起的克隆性暴发。由于猫是常见的家庭宠物，本报告引发了对这些ExPEC菌株人畜共患病潜力（双向）的关注。
