由文化产生的抑制细胞的个体发生。

Ontogeny of culture-generated suppressor cells.

作者信息

Rollwagen F M, Stutman O

出版信息

J Exp Med. 1979 Dec 1;150(6):1359-66. doi: 10.1084/jem.150.6.1359.

DOI:10.1084/jem.150.6.1359

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185730/

Abstract

Culture of murine lymphoid cells without added antigen results in the generation of cells which suppress a variety of in vitro immune responses, such as the mixed lymphocyte response (MLR) and the generation of alloreactive cytotoxic T cells (CTL). The ontogeny of this phenomenon was studied. Cells which suppressed the MLR after preculture were isolated from spleens and hematopoietic livers of fetal and young (less than 1 wk old) mice. On the other hand, the generation of alloreactive CTL could be suppressed only by precultured spleen cells taken from 1-w-old or older mice. The parallel between the development of the suppressor functions and the maturation of the responses they regulate, suggests a possible biological significance of the effect.

摘要

在不添加抗原的情况下培养小鼠淋巴细胞，会产生能够抑制多种体外免疫反应的细胞，如混合淋巴细胞反应（MLR）和同种异体反应性细胞毒性T细胞（CTL）的产生。对这一现象的个体发生进行了研究。从胎儿和幼年（小于1周龄）小鼠的脾脏和造血肝脏中分离出预培养后抑制MLR的细胞。另一方面，只有取自1周龄或更大龄小鼠的预培养脾细胞才能抑制同种异体反应性CTL的产生。抑制功能的发展与其所调节反应的成熟之间的平行关系，提示了这种效应可能具有的生物学意义。

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