• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

小鼠新生抑制性T细胞的Ly表型及作用机制。

Ly phenotype and mechanism of action of mouse neonatal suppressor T cells.

作者信息

Mosier D E, Mathieson B J, Campbell P S

出版信息

J Exp Med. 1977 Jul 1;146(1):59-73. doi: 10.1084/jem.146.1.59.

DOI:10.1084/jem.146.1.59
PMID:406348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2180724/
Abstract

Neonatal suppressor T cells were isolated from the thymuses of 10- to 14-day old BDF mice infected at birth with mouse thymic virus. Such cells were enriched for suppressive activity directed against antibody formation by adult B cells and represented a relatively homogenous population of outer cortical cells. Their surface antigen phenotype was found to be: Ly 1+, Ly 2+, TL+, Thy 1+, and H-2+. The cells were larger and contained more DNA than thymocytes from age-matched controls. These findings identify neonatal suppressor T cells as a unique subpopulation separate from most inducible suppressor cells in the adult mouse. The mechanism of action of neonatal suppressor T cells seems to be a reduction in the number of B cells initially triggered by antigen.

摘要

从出生时感染小鼠胸腺病毒的10至14日龄BDF小鼠的胸腺中分离出新生抑制性T细胞。这类细胞针对成年B细胞抗体形成的抑制活性得到富集，代表了皮质外层细胞中相对同质的群体。发现它们的表面抗原表型为：Ly 1 +、Ly 2 +、TL +、Thy 1 +和H - 2 +。这些细胞比年龄匹配对照的胸腺细胞更大且含有更多DNA。这些发现表明新生抑制性T细胞是与成年小鼠中大多数诱导性抑制细胞不同的独特亚群。新生抑制性T细胞的作用机制似乎是减少最初由抗原触发的B细胞数量。

相似文献

1
Ly phenotype and mechanism of action of mouse neonatal suppressor T cells.小鼠新生抑制性T细胞的Ly表型及作用机制。
J Exp Med. 1977 Jul 1;146(1):59-73. doi: 10.1084/jem.146.1.59.
2
The ontogeny of thymic independent antibody responses in vitro in normal mice and mice with an X-linked B cell defect.正常小鼠和患有X连锁B细胞缺陷的小鼠体外胸腺非依赖抗体反应的个体发生。
J Immunol. 1977 Dec;119(6):1874-8.
3
Induction of B cell priming by neonatal injection of mice with thymic-independent (type 2) antigens.通过向新生小鼠注射非胸腺依赖性（2型）抗原来诱导B细胞致敏。
J Immunol. 1978 Oct;121(4):1453-9.
4
The Ly phenotype of suppressor T cells arising in mice subjected to a graft-versus-host reaction.遭受移植物抗宿主反应的小鼠体内产生的抑制性T细胞的Ly表型。
J Exp Med. 1977 May 1;145(5):1169-75. doi: 10.1084/jem.145.5.1169.
5
Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.带有不同Ly抗原的T淋巴细胞功能亚类。I. 功能不同的T细胞亚类的产生是一个独立于抗原的分化过程。
J Exp Med. 1975 Jun 1;141(6):1376-89. doi: 10.1084/jem.141.6.1376.
6
Identification of early stages of T lymphocyte development in the thymus cortex and medulla.胸腺皮质和髓质中T淋巴细胞早期发育阶段的鉴定。
J Immunol. 1985 Jun;134(6):3632-42.
7
Differentiation of memory T cells to virus plaque-forming cells and cytotoxic T lymphocytes.记忆T细胞向病毒蚀斑形成细胞和细胞毒性T淋巴细胞的分化。
J Exp Med. 1977 Jul 1;146(1):11-21. doi: 10.1084/jem.146.1.11.
8
Phenotypic and functional properties of murine thymocytes. I. Precursors of cytolytic T lymphocytes and interleukin 2-producing cells are all contained within a subpopulation of "mature" thymocytes as analyzed by monoclonal antibodies and flow microfluorometry.小鼠胸腺细胞的表型和功能特性。I. 用单克隆抗体和流式微量荧光测定法分析发现，溶细胞性T淋巴细胞和产生白细胞介素2的细胞的前体都包含在“成熟”胸腺细胞的一个亚群中。
J Exp Med. 1982 Feb 1;155(2):358-79. doi: 10.1084/jem.155.2.358.
9
In vitro responses of CBA/N mice: spleen cells of mice with an X-linked defect that precludes immune responses to several thymus-independent antigens can respond to TNP-lipopolysaccharide.CBA/N小鼠的体外反应：具有X连锁缺陷、无法对多种胸腺非依赖性抗原产生免疫反应的小鼠的脾细胞，能够对三硝基苯-脂多糖产生反应。
J Immunol. 1976 Oct;117(4):1363-9.
10
Ontogeny of mouse T-lymphocyte function.小鼠T淋巴细胞功能的个体发生
Fed Proc. 1975 Feb;34(2):137-40.

引用本文的文献

1
Postnatal development of T cells. III. Thymus independency of T-cell-dependent antigen response in the neonatal spleen.T细胞的出生后发育。III. 新生小鼠脾脏中T细胞依赖性抗原反应的胸腺非依赖性
Immunology. 1982 May;46(1):209-14.
2
Immunoregulatory changes induced by total lymphoid irradiation. II. Development of thymus-leukemia antigen-positive and -negative suppressor T cells that differ in their regulatory function.全身淋巴照射诱导的免疫调节变化。II. 胸腺白血病抗原阳性和阴性抑制性T细胞的发育，其调节功能不同。
J Exp Med. 1981 Jul 1;154(1):13-23. doi: 10.1084/jem.154.1.13.
3
The surface phenotype of a suppressor cell of delayed-type hypersensitivity in the mouse.小鼠迟发型超敏反应抑制细胞的表面表型。
Immunology. 1980 May;40(1):87-96.
4
Concanavalin-induced suppressor cells: characterization on the basis of corticosteroid and radiation sensitivity.伴刀豆球蛋白诱导的抑制细胞：基于皮质类固醇和辐射敏感性的特征分析
Immunology. 1982 Sep;47(1):85-90.
5
Suppressor T cell memory. II. The role of memory suppressor T cells in tolerance to human gamma globulin.抑制性T细胞记忆。II. 记忆性抑制性T细胞在对人丙种球蛋白耐受性中的作用。
J Exp Med. 1983 Mar 1;157(3):957-73. doi: 10.1084/jem.157.3.957.
6
Characterization of the suppressor cell activity in human cord blood lymphocytes.人脐血淋巴细胞中抑制细胞活性的特征分析。
J Clin Invest. 1981 Dec;68(6):1577-85. doi: 10.1172/jci110412.
7
H-2-mediated resistance to an ecotropic type C retrovirus: localization of controlling genes and ontogenic studies of resistance.H-2介导的对亲嗜性C型逆转录病毒的抗性：控制基因的定位及抗性的个体发生学研究
Immunogenetics. 1980;11(5):451-65. doi: 10.1007/BF01567814.
8
Generation in vitro of alloreactive lymphocytes is suppressed by the addition of spleen cells from mice infected with lymphocytic choriomeningitis virus.通过添加感染淋巴细胞性脉络丛脑膜炎病毒的小鼠的脾细胞，可抑制同种反应性淋巴细胞的体外生成。
Med Microbiol Immunol. 1986;175(6):317-24. doi: 10.1007/BF02123868.
9
Suppression of cytotoxic responses by a supernatant factor derived from Mycoplasma hyorhinis-infected mammalian cell lines.源自感染猪鼻支原体的哺乳动物细胞系的一种上清因子对细胞毒性反应的抑制作用。
Infect Immun. 1988 Jan;56(1):197-203. doi: 10.1128/iai.56.1.197-203.1988.
10
The role of antigen presentation in the ontogeny of immune responses to herpes simplex virus.抗原呈递在单纯疱疹病毒免疫反应个体发生中的作用。
Clin Exp Immunol. 1988 May;72(2):201-6.

本文引用的文献

1
CYTOTOXIC TEST FOR DEMONSTRATION OF MOUSE ANTIBODY.用于证明小鼠抗体的细胞毒性试验。
Methods Med Res. 1964;10:39-47.
2
A new mouse virus causing necrosis of the thymus in newborn mice.一种导致新生小鼠胸腺坏死的新型小鼠病毒。
J Exp Med. 1961 May 1;113(5):831-44. doi: 10.1084/jem.113.5.831.
3
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
4
Isogeneic lymphocyte interaction: recognition of self antigens by cells of the neonatal thymus.同基因淋巴细胞相互作用：新生胸腺细胞对自身抗原的识别。
Proc Natl Acad Sci U S A. 1970 Oct;67(2):613-9. doi: 10.1073/pnas.67.2.613.
5
Improved complementation in the cytotoxic test.细胞毒性试验中补体作用的增强。
Transplantation. 1970 Nov;10(5):446-9. doi: 10.1097/00007890-197011000-00019.
6
Biological expressions of lymphocyte activation. II. Generation of a population of thymus-derived suppressor lymphocytes.淋巴细胞激活的生物学表现。II. 胸腺来源抑制性淋巴细胞群体的产生。
J Exp Med. 1973 Mar 1;137(3):649-59. doi: 10.1084/jem.137.3.649.
7
Stimulation of mouse thymocytes by syngeneic spleen cells in mixed lymphocyte reactions.在混合淋巴细胞反应中，同基因脾细胞对小鼠胸腺细胞的刺激。
Adv Exp Med Biol. 1973;29(0):217-23. doi: 10.1007/978-1-4615-9017-0_32.
8
Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.带有不同Ly抗原的T淋巴细胞功能亚类。II. Ly+细胞亚类在杀伤活性产生中的合作。
J Exp Med. 1975 Jun 1;141(6):1390-9. doi: 10.1084/jem.141.6.1390.
9
Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.带有不同Ly抗原的T淋巴细胞功能亚类。I. 功能不同的T细胞亚类的产生是一个独立于抗原的分化过程。
J Exp Med. 1975 Jun 1;141(6):1376-89. doi: 10.1084/jem.141.6.1376.
10
Stimulation of a T-independent primary anti-hapten response in vitro by TNP-lipopolysaccharide (TNP-LPS).通过三硝基苯脂多糖（TNP-LPS）在体外刺激非T细胞依赖性初次抗半抗原反应。
J Immunol. 1975 Jan;114(1 Pt 2):360-4.