小鼠新生抑制性T细胞的Ly表型及作用机制。
Ly phenotype and mechanism of action of mouse neonatal suppressor T cells.
作者信息
Mosier D E, Mathieson B J, Campbell P S
出版信息
J Exp Med. 1977 Jul 1;146(1):59-73. doi: 10.1084/jem.146.1.59.
Abstract
Neonatal suppressor T cells were isolated from the thymuses of 10- to 14-day old BDF mice infected at birth with mouse thymic virus. Such cells were enriched for suppressive activity directed against antibody formation by adult B cells and represented a relatively homogenous population of outer cortical cells. Their surface antigen phenotype was found to be: Ly 1+, Ly 2+, TL+, Thy 1+, and H-2+. The cells were larger and contained more DNA than thymocytes from age-matched controls. These findings identify neonatal suppressor T cells as a unique subpopulation separate from most inducible suppressor cells in the adult mouse. The mechanism of action of neonatal suppressor T cells seems to be a reduction in the number of B cells initially triggered by antigen.
摘要
从出生时感染小鼠胸腺病毒的10至14日龄BDF小鼠的胸腺中分离出新生抑制性T细胞。这类细胞针对成年B细胞抗体形成的抑制活性得到富集，代表了皮质外层细胞中相对同质的群体。发现它们的表面抗原表型为：Ly 1 +、Ly 2 +、TL +、Thy 1 +和H - 2 +。这些细胞比年龄匹配对照的胸腺细胞更大且含有更多DNA。这些发现表明新生抑制性T细胞是与成年小鼠中大多数诱导性抑制细胞不同的独特亚群。新生抑制性T细胞的作用机制似乎是减少最初由抗原触发的B细胞数量。
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