体外培养过程中非特异性抑制性T细胞的出现。
Appearance of non-specific suppressor T cells during in vitro culture.
作者信息
Parish C R
出版信息
Immunology. 1977 Oct;33(4):597-603.
Abstract
It was found that when normal mouse spleen cells were cultured for 4 days they were capable of non-specifically suppressing the in vitro antibody response of non-precultured spleen. The suppression was mediated by a subpopulation of viable, non-adherent, T lymphocytes with the surface phenotype Ly-1+, Ly-2- and Ia-. Furthermore, it appeared that the suppressor cells were responding to foetal calf serum antigens present in the tissue culture medium and were subsequently inactivating either B lymphocytes or accessory cells required for antibody formation, which had passively absorbed these antigens.
摘要
研究发现，正常小鼠脾细胞培养4天后能够非特异性抑制未预培养脾细胞的体外抗体反应。这种抑制作用由一群具有存活、非黏附特性的T淋巴细胞介导，其表面表型为Ly-1+、Ly-2-和Ia-。此外，似乎抑制细胞对组织培养基中存在的胎牛血清抗原产生反应，随后使被动吸收了这些抗原的抗体形成所需的B淋巴细胞或辅助细胞失活。
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