体外培养过程中非特异性抑制性T细胞的出现。
Appearance of non-specific suppressor T cells during in vitro culture.
作者信息
Parish C R
出版信息
Immunology. 1977 Oct;33(4):597-603.
Abstract
It was found that when normal mouse spleen cells were cultured for 4 days they were capable of non-specifically suppressing the in vitro antibody response of non-precultured spleen. The suppression was mediated by a subpopulation of viable, non-adherent, T lymphocytes with the surface phenotype Ly-1+, Ly-2- and Ia-. Furthermore, it appeared that the suppressor cells were responding to foetal calf serum antigens present in the tissue culture medium and were subsequently inactivating either B lymphocytes or accessory cells required for antibody formation, which had passively absorbed these antigens.
摘要
研究发现，正常小鼠脾细胞培养4天后能够非特异性抑制未预培养脾细胞的体外抗体反应。这种抑制作用由一群具有存活、非黏附特性的T淋巴细胞介导，其表面表型为Ly-1+、Ly-2-和Ia-。此外，似乎抑制细胞对组织培养基中存在的胎牛血清抗原产生反应，随后使被动吸收了这些抗原的抗体形成所需的B淋巴细胞或辅助细胞失活。
相似文献
1
Appearance of non-specific suppressor T cells during in vitro culture.
Immunology. 1977 Oct;33(4):597-603.
2
Generation of specific helper cells and suppressor cells in vitro for the IgE and IgG antibody responses.
J Immunol. 1976 Jul;117(1):40-7.
3
Functional heterogeneity among the T-derived lymphocytes of the mouse. IV. Nature of spontaneously induced suppressor cells.
J Immunol. 1975 Apr;114(4):1345-7.
4
Induction of suppressor T cells of antibody formation under conditions that preferentially stimulate DTH.
J Immunol. 1980 Jul;125(1):197-201.
5
6
Production of BSF-1 during an in vivo, T-dependent immune response.
J Immunol. 1986 Nov 1;137(9):2878-85.
7
The evolution of immunosuppressive cell populations in experimental mycobacterial infection.
J Immunol. 1978 May;120(5):1709-16.
8
9
Role of self carriers in the immune response and tolerance. VI. Induction and reversal of TNP-modified self unresponsiveness in vitro.
J Immunol. 1980 Dec;125(6):2380-4.
10
Differential regulatory effects of accessory cells on the generation of cell-mediated immune reactions.
J Immunol. 1975 Feb;114(2 Pt 1):692-5.
引用本文的文献
1
Induction of autoimmunity in normal mice by thymectomy and administration of polyclonal B cell activators: association with contrasuppressor function.
Clin Exp Immunol. 1983 Mar;51(3):579-86.
2
3
The surface phenotype of a suppressor cell of delayed-type hypersensitivity in the mouse.
Immunology. 1980 May;40(1):87-96.
4
Suppressor T cells activated in a primary in vitro response to non-major histocompatibility alloantigens.
J Exp Med. 1982 Nov 1;156(5):1398-414. doi: 10.1084/jem.156.5.1398.
5
Induction of acetylcholine receptor-specific suppression. An in vitro model of antigen-specific immunosuppression in myasthenia gravis.
J Exp Med. 1984 Jan 1;159(1):292-304. doi: 10.1084/jem.159.1.292.
6
Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease.
J Exp Med. 1985 Jan 1;161(1):72-87. doi: 10.1084/jem.161.1.72.
7
Regulation of egg antigen-induced in vitro proliferative response by splenic suppressor T cells in murine Schistosoma japonicum infection.
Infect Immun. 1985 Sep;49(3):635-40. doi: 10.1128/iai.49.3.635-640.1985.
8
9
Induction of suppression and help during in vitro immunization of mouse spleen cells.
Immunology. 1979 Apr;36(4):743-52.
10
Ontogeny of culture-generated suppressor cells.
J Exp Med. 1979 Dec 1;150(6):1359-66. doi: 10.1084/jem.150.6.1359.
本文引用的文献
1
ANTIGENS IN IMMUNITY. I. PREPARATION AND PROPERTIES OF FLAGELLAR ANTIGENS FROM SALMONELLA ADELAIDE.
Aust J Exp Biol Med Sci. 1964 Jun;42:267-82.
2
Further improvements in the plaque technique for detecting single antibody-forming cells.
Immunology. 1968 Apr;14(4):599-600.
3
Antigenic competition: a review of nonspecific antigen-induced suppression.
Adv Immunol. 1974;18:133-68. doi: 10.1016/s0065-2776(08)60309-0.
4
Immune responses in vitro. I. Culture conditions for antibody synthesis.
Cell Immunol. 1972 Feb;3(2):264-76. doi: 10.1016/0008-8749(72)90165-7.
5
Specific versus nonspecific target cell destruction by T lymphocytes sensitized in vitro. II. Responsible factors for nonspecific destruction.
Cell Immunol. 1974 Mar 15;10(3):359-70. doi: 10.1016/0008-8749(74)90128-2.
6
Induction of specific helper cells in vitro.
Nat New Biol. 1973 Oct 31;245(148):285-6. doi: 10.1038/newbio245285a0.
7
Separation of suppressor and killer T cells by surgace phenotype.
Nature. 1976 Aug 5;262(5568):495-7. doi: 10.1038/262495a0.
8
Secretion of Ia antigens by a subpopulation of T cells which are Ly-1+, Ly-2-, and Ia-.
J Exp Med. 1976 Sep 1;144(3):847-51. doi: 10.1084/jem.144.3.847.
9
Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression.
J Exp Med. 1976 Jul 1;144(1):10-9. doi: 10.1084/jem.144.1.10.
10
Different Ly antigen phenotypes of in vitro induced helper and suppressor cells.
Nature. 1975 Dec 18;258(5536):614-6. doi: 10.1038/258614a0.
Zotero 插件