Bárdos Julia I, Ashcroft Margaret
Cell Growth Regulation and Angiogenesis Laboratory, Cancer Research UK, Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, UK.
Biochim Biophys Acta. 2005 Jul 25;1755(2):107-20. doi: 10.1016/j.bbcan.2005.05.001.
Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic response in eukaryotic cells, regulating the expression of a myriad of genes involved in oxygen transport, glucose uptake and glycolysis and angiogenesis. Deregulation of HIF-1 activity occurs in many human cancers, usually at the level of the HIF-1alpha subunit. HIF-1 is regulated by a variety of mechanisms including transcription, translation post-translational modification, protein-protein interaction and degradation. Our understanding of the key signalling pathways that regulate HIF-1 has significantly progressed in recent years and has highlighted the potential for targeting the HIF-1 pathway as a basis for the development of new cancer therapies.
缺氧诱导因子-1（HIF-1）是真核细胞缺氧反应的关键转录调节因子，可调节众多参与氧运输、葡萄糖摄取与糖酵解以及血管生成的基因的表达。HIF-1活性失调在许多人类癌症中都会出现，通常发生在HIF-1α亚基水平。HIF-1受多种机制调节，包括转录、翻译、翻译后修饰、蛋白质-蛋白质相互作用和降解。近年来，我们对调节HIF-1的关键信号通路的理解有了显著进展，并突出了将HIF-1通路作为开发新癌症治疗方法基础的靶向潜力。
