Kajabwangu Rogers, Izudi Jonathan, Bazira Joel, Ssedyabane Frank, Turanzomwe Stuart, Birungi Abraham, Ngonzi Joseph, Bajunirwe Francis, Randall Thomas C
Department of Obstetrics and Gynaecology, Faculty of Medicine, Mbarara University of Science and Technology, P.O. Box 1410 Mbarara Uganda.
Department of Community Health, Mbarara University of Science and Technology, P.O. Box 1410 Mbarara Uganda.
Gynecol Oncol Rep. 2024 Jun 22;54:101438. doi: 10.1016/j.gore.2024.101438. eCollection 2024 Aug.
Despite the global implementation of preventive strategies against Human Papilloma Virus (HPV) infection, the incidence of invasive cervical cancer rose by nearly 1.3-fold, from 471,000 annual cases in 2000 to 604,000 cases in 2020. With over 340,000 deaths annually, cervical cancer is the fourth leading cause of cancer mortality in women globally. There is a need to understand other factors besides HPV such as metabolic syndrome (MetS) that potentially influence the onset and progression of cervical cancer. In this narrative review, we describe evidence showing that Metabolic syndrome (MetS) increases the risk for cervical cancer and worsens its prognosis. Combined screening for MetS and cervical cancer has potential to significantly reduce morbidity and mortality in women with cervical cancer.
尽管全球都在实施针对人乳头瘤病毒（HPV）感染的预防策略，但浸润性宫颈癌的发病率仍上升了近1.3倍，从2000年的每年47.1万例增至2020年的60.4万例。宫颈癌每年导致超过34万人死亡，是全球女性癌症死亡的第四大主要原因。有必要了解除HPV之外的其他因素，如代谢综合征（MetS），其可能影响宫颈癌的发生和发展。在这篇叙述性综述中，我们阐述了证据表明代谢综合征（MetS）会增加患宫颈癌的风险并使预后恶化。联合筛查代谢综合征和宫颈癌有可能显著降低宫颈癌女性的发病率和死亡率。
