Marcelja S
Department of Applied Mathematics, Research School of Physical Sciences and Engineering, Australian National University, Canberra ACT.
Biophys J. 1992 May;61(5):1117-21. doi: 10.1016/S0006-3495(92)81921-5.
We consider electrical double layer interaction under the conditions typically encountered during membrane fusion. Within the physiological concentration range of monovalent electrolytes the interaction is repulsive and the Poisson-Boltzmann calculation may be used to evaluate the force. When divalent counterions are added, strong ion-ion correlations make the Poisson-Boltzmann approximation inapplicable. We use the anisotropic hypernetted chain method to show that in the presence of small amounts of divalent counterions in adsorption equilibrium with the surfaces, the double layer interaction turns into attraction. This attractive electrostatic force may be the balancing contribution controlling membrane adhesion.
我们考虑了膜融合过程中通常遇到的条件下的双电层相互作用。在单价电解质的生理浓度范围内，相互作用是排斥性的，泊松-玻尔兹曼计算可用于评估该力。当加入二价抗衡离子时，强离子-离子相关性使泊松-玻尔兹曼近似不适用。我们使用各向异性超网链方法表明，在与表面处于吸附平衡的少量二价抗衡离子存在下，双电层相互作用转变为吸引力。这种有吸引力的静电力可能是控制膜粘附的平衡贡献。
