Berroëta C, Provenchère S, Quintard H, Ibrahim H, Paquin S, Philip I
Département d'anesthésie-réanimation, hôpital Bichat-Claude-Bernard, Paris.
Arch Mal Coeur Vaiss. 2004 Oct;97(10):979-85.
Hypertension is a frequent condition among adults. It is one of the major risk factors of atherosclerotic diseases. Anesthetologists are frequently confronted to the management of treated or untreated hypertensive patients whose major risk during that period concerns the potential association with coronary artery disease. Therefore, the preoperative assessment should be insured of an adequate control of blood pressure, the presence of potential target organ damage and especially the detection an underlying coronary disease and its importance. The risk of cardiovascular complications and consecutively the preoperative check-up depend of the type of surgery scheduled. Preoperative systolic blood pressures (SBP) below 180 mmHg and diastolic blood pressures (DBP) below 110 mmHg are recommended. Due to their efficacy, tolerability and the easiness of their use, dihydropyridins and beta-blockers are the most frequent drugs used in the peri-operative period. Many studies evidenced the benefit of beta-blocking agents in patients with definite or potential coronary artery disease during the immediate period of major surgery, with not only a decrease of serious cardiac complications and post-operative mortality but also an improvement of mid- and longterm prognosis. There is no evidence to privilege any type of anesthesia. A respect of hemodynamic conditions (avoidance of severe hypotension and tachycardia) reduces the incidence of ischemic complications. The hemodynamic stability is obtained with an adapted anesthesia and the use of intravenous vasoconstrictive or vasodilator agents as well as beta-blockers (esmolol). The diagnosis of perioperative myocardial infarction is based on the measurement of seric concentrations of cardiac Troponin isoforms (TnI or TnT).
高血压在成年人中很常见。它是动脉粥样硬化疾病的主要危险因素之一。麻醉医生经常面临已治疗或未治疗的高血压患者的管理问题,在此期间,主要风险在于与冠状动脉疾病的潜在关联。因此,术前评估应确保血压得到充分控制,存在潜在的靶器官损害,特别是检测潜在的冠状动脉疾病及其严重程度。心血管并发症的风险以及术前检查取决于预定手术的类型。建议术前收缩压(SBP)低于180 mmHg,舒张压(DBP)低于110 mmHg。由于其有效性、耐受性和使用便利性,二氢吡啶类和β受体阻滞剂是围手术期最常用的药物。许多研究证明,在大手术的即刻期间,β受体阻滞剂对患有明确或潜在冠状动脉疾病的患者有益,不仅可降低严重心脏并发症和术后死亡率,还可改善中长期预后。没有证据表明偏爱任何一种麻醉方式。维持血流动力学稳定(避免严重低血压和心动过速)可降低缺血性并发症的发生率。通过适当的麻醉以及使用静脉血管收缩剂或血管扩张剂以及β受体阻滞剂(艾司洛尔)可实现血流动力学稳定。围手术期心肌梗死的诊断基于血清心肌肌钙蛋白同工型(TnI或TnT)浓度的测定。