Rabijns Anja, Barre Annick, Van Damme Els J M, Peumans Willy J, De Ranter Camiel J, Rougé Pierre
Laboratory of Analytical Chemistry and Medicinal Physicochemistry, Faculty of Pharmaceutical Sciences, K. U. Leuven, Belgium.
FEBS J. 2005 Jul;272(14):3725-32. doi: 10.1111/j.1742-4658.2005.04801.x.
The structures of MornigaM and the MornigaM-mannose complex have been determined at 1.8 A and 2.0 A resolution, respectively. Both structures adopt the typical beta-prism motif found in other jacalin-related lectins and their tetrameric assembly closely resembles that of jacalin. The carbohydrate-binding cavity of MornigaM readily binds mannose. No major structural rearrangements can be observed in MornigaM upon binding of mannose. These results allow corroboration of the structure-function relationships within the small group of Moraceae lectins.
已分别在1.8埃和2.0埃分辨率下确定了莫尼加M（MornigaM）及其与甘露糖复合物的结构。两种结构均采用了在其他与jacalin相关的凝集素中发现的典型β-棱柱基序，并且它们的四聚体组装与jacalin的非常相似。莫尼加M的碳水化合物结合腔很容易结合甘露糖。在结合甘露糖后，未观察到莫尼加M有重大的结构重排。这些结果证实了桑科凝集素这一小类中的结构-功能关系。
