Levri Kara M, Ketvertis Kari, Deramo Mark, Merenstein Joel H, D'Amico Frank
University of Pittsburgh Medical Center/St. Margaret, 3937 Butler Street, Pittsburgh, PA 15201, USA.
J Fam Pract. 2005 Jul;54(7):613-20.
To assess the efficacy of oral probiotics in adults with lactose intolerance through a systematic review of its effects on symptoms and breath hydrogen tests, and whether adding probiotics to nonfermented dairy products decreases lactose intolerance at that meal.
We searched randomized controlled trials published between 1966 and December 2002. Databases in the search strategy included Medline and AMED. We reviewed references of clinical trials and contacted authors of major articles and manufacturers of probiotic commercial products. Quality assessment was based on the McMaster guides and was performed by 5 independent reviewers. Data extraction was performed by 2 reviewers.
A master list of 90 articles was compiled. Ten articles met inclusion and exclusion criteria and were consistent with our clinical question. Of the 9 studies that measured breath hydrogen, 3 were positive, 3 were negative, and 3 had both positive and negative results. Of the 7 studies that measured symptoms, 1 yielded positive results, 5 were negative, and 1 had both positive and negative outcomes.
Probiotic supplementation in general did not alleviate the symptoms and signs of lactose intolerance in adults in this review. Some evidence suggests that specific strains, concentrations, and preparations are effective. Further clinical trials of specific strains and concentrations are necessary to delineate this potential therapeutic relationship.
通过系统评价口服益生菌对乳糖不耐受成人症状及呼气氢试验的影响，以及向非发酵乳制品中添加益生菌是否能减轻该餐时的乳糖不耐受情况，来评估口服益生菌的疗效。
我们检索了1966年至2002年12月间发表的随机对照试验。检索策略中的数据库包括Medline和AMED。我们查阅了临床试验的参考文献，并联系了主要文章的作者及益生菌商业产品的制造商。质量评估基于麦克马斯特指南，由5名独立评审员进行。数据提取由2名评审员完成。
编制了一份包含90篇文章的主列表。10篇文章符合纳入和排除标准，且与我们的临床问题相符。在9项测量呼气氢的研究中，3项结果为阳性，3项为阴性，3项既有阳性结果又有阴性结果。在7项测量症状的研究中，1项产生了阳性结果，5项为阴性，1项既有阳性结果又有阴性结果。
在本综述中，一般情况下补充益生菌并不能缓解成人乳糖不耐受的症状和体征。一些证据表明特定菌株、浓度和制剂是有效的。需要进一步开展针对特定菌株和浓度的临床试验，以明确这种潜在的治疗关系。
