Wieraszko Andrzej, Armani Jacquline, Maqsood Nida, Raja Haroon, Philip Susan
Department of Biology/Program in Neuroscience, The College of Staten Island/CUNY, NY 10314, USA.
Brain Res. 2005 Aug 9;1052(2):232-5. doi: 10.1016/j.brainres.2005.06.034.
The influence of pulsed magnetic fields (PMF) on the release and uptake of glutamate was investigated. While the release was examined using hippocampal slices, synaptosomes were chosen to characterize the uptake process. (3)H-D-aspartate was used as a marker of glutamergic transmission. The pulsed magnetic fields (9-15 mT) applied according to the pattern which induced epileptic discharges in hippocampus amplified and attenuated the release and uptake of glutamate, respectively. However, the magnetic fields which induced an increase in neuronal excitability without concomitant seizures amplified both processes. These results confirm our previous reports and indicate that the glutamergic synapses are the target of magnetic fields action.
研究了脉冲磁场（PMF）对谷氨酸释放和摄取的影响。在使用海马切片检测释放情况时，选用突触体来表征摄取过程。用（3）H-D-天冬氨酸作为谷氨酸能传递的标志物。按照能在海马中诱发癫痫放电的模式施加的脉冲磁场（9 - 15毫特斯拉）分别增强和减弱了谷氨酸的释放和摄取。然而，那些能增加神经元兴奋性但不伴有癫痫发作的磁场则增强了这两个过程。这些结果证实了我们之前的报道，并表明谷氨酸能突触是磁场作用的靶点。
