Ahmed Zaghloul, Wieraszko Andrzej
Department of Physical Therapy, The College of Staten Island/CUNY, 2800 Victory Boulevard, Staten Island, New York 10314, USA.
Brain Res. 2008 Jul 24;1221:30-40. doi: 10.1016/j.brainres.2008.05.007. Epub 2008 May 15.
The influence of a pulsed magnetic field (PMF) on hippocampal evoked potentials has been investigated in vitro. The exposure to PMF (0.16 Hz, 15 mT) applied for 30 min amplified the population spike and the slope of EPSP recorded from stratum pyramidale and stratum radiatum respectively. This amplification was additive to previously induced LTP and occurred in an NMDA-independent way. The increase in the activity of electrical synapses accompanied PMF-induced amplification of evoked potentials. Since PMF exposure modified paired-pulse facilitation and paired-pulse inhibition, it was concluded that it modifies excitatory and inhibitory processes in the hippocampus. Control experiments revealed that observed effects were exclusively related to PMF exposure. The results support and extend our previous research indicating a significant influence of magnetic fields on hippocampal physiology.
已经在体外研究了脉冲磁场（PMF）对海马诱发电位的影响。暴露于频率为0.16Hz、强度为15mT的PMF 30分钟，分别增强了从锥体层和辐射层记录到的群体峰电位和兴奋性突触后电位（EPSP）的斜率。这种增强作用与先前诱导的长时程增强（LTP）具有叠加性，并且以不依赖N-甲基-D-天冬氨酸（NMDA）的方式发生。电突触活动的增加伴随着PMF诱导的诱发电位增强。由于PMF暴露改变了双脉冲易化和双脉冲抑制，因此得出结论，它改变了海马中的兴奋性和抑制性过程。对照实验表明，观察到的效应仅与PMF暴露有关。这些结果支持并扩展了我们之前的研究，表明磁场对海马生理有显著影响。
