Gönenç Aymelek, Erten Derya, Aslan Sabahattin, Akinci Melih, Simşek Bolkan, Torun Meral
Department of Biochemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
Cell Biol Int. 2006 Apr;30(4):376-80. doi: 10.1016/j.cellbi.2006.02.005. Epub 2006 Mar 6.
Changes in the levels of malondialdehyde (MDA), nitrate and nitrite (as an index of nitric oxide production), lipid hydroperoxide (LOH), total antioxidant capacity (TAC), lipids (total cholesterol and triglycerides) and lipoproteins (HDL- and LDL-cholesterol) were estimated in breast cancer patients (n = 15) and benign breast disease (n = 15). Serum and tissue MDA levels were found to be decreased in breast cancer patients compared to the benign group (p < 0.05). In contrast, nitrate and nitrite levels were increased in serum and tissue of the cancer group compared to benign breast disease patients (p < 0.05). Compared to the benign group, tissue TAC levels were elevated in the breast cancer patient group (p < 0.05). Total cholesterol and HDL-cholesterol were elevated in the benign group compared with cancer patients (p < 0.05). These findings support the hypothesis that lipid peroxidation in serum and tissue of benign breast disease is greater than in breast cancer. However, the enhanced levels of nitric oxide may be in response to inflammation in patients with breast cancer. Total antioxidant status is lower in benign tissue than in cancerous tissue, probably to compensate for this elevated free radical production.
对15例乳腺癌患者和15例乳腺良性疾病患者的丙二醛（MDA）、硝酸盐和亚硝酸盐（作为一氧化氮产生的指标）、脂质过氧化氢（LOH）、总抗氧化能力（TAC）、脂质（总胆固醇和甘油三酯）以及脂蛋白（高密度脂蛋白胆固醇和低密度脂蛋白胆固醇）水平进行了评估。结果发现，与良性组相比，乳腺癌患者的血清和组织MDA水平降低（p < 0.05）。相反，与乳腺良性疾病患者相比，癌症组血清和组织中的硝酸盐和亚硝酸盐水平升高（p < 0.05）。与良性组相比，乳腺癌患者组的组织TAC水平升高（p < 0.05）。与癌症患者相比，良性组的总胆固醇和高密度脂蛋白胆固醇升高（p < 0.05）。这些发现支持了以下假设：乳腺良性疾病血清和组织中的脂质过氧化作用大于乳腺癌。然而，一氧化氮水平的升高可能是对乳腺癌患者炎症的反应。良性组织中的总抗氧化状态低于癌组织，这可能是为了补偿这种升高的自由基产生。
