Collins Laura R, Hall Richard W, Dajani Nafisa K, Wendel Paul J, Lowery Curtis L, Kay Helen H
Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
J Matern Fetal Neonatal Med. 2005 Jun;17(6):417-21. doi: 10.1080/14767050500123996.
Vasoconstriction was observed in the fetal middle cerebral and umbilical arteries by Doppler assessment at 27 weeks gestation in a patient requiring continuous morphine infusion for pain control. Fetal heart tracings were also concerning. Fetal status improved after a change to fentanyl infusion, a shorter acting opioid. Caution is recommended when long-term chronic narcotic infusion is used in pregnancy.
在一名因疼痛控制需要持续输注吗啡的患者中，于妊娠27周时通过多普勒评估观察到胎儿大脑中动脉和脐动脉出现血管收缩。胎儿心率监测结果也令人担忧。改用作用时间较短的阿片类药物芬太尼输注后，胎儿状况有所改善。建议在孕期使用长期慢性麻醉剂输注时要谨慎。
