Büchler M, Friess H, Uhl W, Beger H G
Department of General Surgery, University of Ulm, FRG.
Eur Surg Res. 1992;24 Suppl 1:85-8. doi: 10.1159/000129243.
There are several well-standardized models of experimental acute pancreatitis such as the closed duodenal loop technique, cholecystokinin or cerulein stimulation, duct injection and diet-induced acute experimental pancreatitis. With regard to human acute pancreatitis, experimental models in animals have a considerable high clinical relevance if the subject of investigation concerns pathogenetic, morphological and diagnostic approaches to the disease; as regards the treatment modalities and causative therapy of acute pancreatitis, experimental models in animals up to now seem to be far away from the clinical situation and therefore these protocols have low clinical relevance. The reasons for this discrepancy are outlined in this paper.
有几种标准化良好的实验性急性胰腺炎模型，如闭合十二指肠襻技术、胆囊收缩素或雨蛙肽刺激、导管注射和饮食诱导的急性实验性胰腺炎。关于人类急性胰腺炎，如果研究主题涉及该疾病的发病机制、形态学和诊断方法，动物实验模型具有相当高的临床相关性；至于急性胰腺炎的治疗方式和病因治疗，迄今为止动物实验模型似乎与临床情况相差甚远，因此这些方案的临床相关性较低。本文概述了这种差异的原因。
