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生理稳定的钒（IV）卟啉作为一类新型抗HIV药物。

Physiologically stable vanadium(IV) porphyrins as a new class of anti-HIV agents.

作者信息

Wong Suk-Yu, Wai-Yin Sun Raymond, Chung Nancy P-Y, Lin Chen-Lung, Che Chi-Ming

机构信息

Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, China.

出版信息

Chem Commun (Camb). 2005 Jul 28(28):3544-6. doi: 10.1039/b503535j. Epub 2005 Jun 1.

DOI:10.1039/b503535j
PMID:16010318
Abstract

The water soluble oxovanadium(IV) tetraarylporphyrin has demonstrated excellent solution stability against glutathione reduction and high potency (5 microM, 97% inhibition) in inhibiting HIV-1 replication in Hut/CCR5 cells.

摘要

水溶性四芳基卟啉氧钒（IV）已证明在谷胱甘肽还原反应中具有出色的溶液稳定性，并且在抑制Hut/CCR5细胞中的HIV-1复制方面具有高效性（5微摩尔，抑制率97%）。

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