Iwase Satoshi
Aichi Medical University, Nagakute, Aichi, Japan.
Acta Astronaut. 2005 Jul-Oct;57(2-8):75-80. doi: 10.1016/j.actaastro.2005.03.013.
To test the effectiveness of centrifuge-induced artificial gravity with ergometric exercise, 12 healthy young men (20.7 +/- 1.9 yr) were exposed to simulated microgravity for 14 days of -6 degrees head-down bedrest. Half the subjects were randomly selected and loaded 1.2 G artificial gravity with 60 W (four out of six subjects) or 40 W (two out of six subjects) of ergometric workload on days 1, 2, 3, 5, 7, 9, 11, 12, 13, 14 (CM group). The rest of the subjects served as the control. Anti-G score, defined as the G-load x running time to the endpoint, was significantly elongated by the load of the centrifuge-ergometer. Plasma volume loss was suppressed (-5.0 +/- 2.4 vs. -16.4 +/- 1.9%), and fluid volume shift was prevented by the countermeasure load. Elevated heart rate and muscle sympathetic nerve activity after bedrest were counteracted, and exaggerated response to head-up tilt was also suppressed. Centrifuge-induced artificial gravity with exercise is effective in preventing cardiovascular deconditioning due to microgravity exposure, however, an effective and appropriate regimen (magnitude of G-load and exercise workload) should be determined in future studies.
为了测试离心诱导的人工重力结合测力运动的效果，12名健康年轻男性（20.7±1.9岁）接受了为期14天的-6度头低位卧床休息模拟微重力环境。随机选择一半受试者，在第1、2、3、5、7、9、11、12、13、14天加载1.2G人工重力，并分别施加60W（6名受试者中的4名）或40W（6名受试者中的2名）的测力工作量（CM组）。其余受试者作为对照组。抗G评分定义为G负荷乘以到达终点的跑步时间，离心机-测力计的负荷使其显著延长。血浆容量损失得到抑制（-5.0±2.4%对-16.4±1.9%），且通过对策负荷防止了液体容量转移。卧床休息后升高的心率和肌肉交感神经活动得到抵消，对抬头倾斜的过度反应也受到抑制。离心诱导的人工重力结合运动可有效预防因微重力暴露导致的心血管功能失调，然而，未来研究应确定有效且合适的方案（G负荷大小和运动工作量）。
