Clément Gilles, Rittweger Jörn, Nitsche Andrea, Doering Wolfgang, Frings-Meuthen Petra, Hand Olga, Frett Timo, Noppe Alexandra, Paulke Freia, Lecheler Leopold, Jordan Jens, Stern Claudia, Mulder Edwin
KBR, Houston, TX, United States.
Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany.
Front Physiol. 2022 Sep 8;13:976926. doi: 10.3389/fphys.2022.976926. eCollection 2022.
A comprehensive strategy is required to mitigate risks to astronauts' health, well-being, and performance. This strategy includes developing countermeasures to prevent or reduce adverse responses to the stressors astronauts encounter during spaceflight, such as weightlessness. Because artificial gravity (AG) by centrifugation simultaneously affects all physiological systems, AG could mitigate the effects of weightlessness in multiple systems. In 2019, NASA and the German Aerospace Center conducted a 60-days Artificial Gravity Bed Rest Study with the European Space Agency (AGBRESA). The objectives of this study were to 1) determine if 30 min of AG daily is protective during head down bed rest, and 2) compare the protective effects of a single daily bout (30 min) of AG versus multiple daily bouts (6 × 5 min) of AG (1 Gz at the center of mass) on physiological functions that are affected by weightlessness and by head-down tilt bed rest. The AGBRESA study involved a comprehensive suite of standard and innovative technologies to characterize changes in a broad spectrum of physiological systems. The current article is intended to provide a detailed overview of the methods used during AGBRESA.
需要一个全面的策略来降低对宇航员健康、福祉和工作表现的风险。该策略包括制定应对措施，以预防或减少宇航员在太空飞行期间遇到的压力源（如失重）所产生的不良反应。由于通过离心产生的人工重力（AG）会同时影响所有生理系统，因此AG可以减轻失重对多个系统的影响。2019年，美国国家航空航天局（NASA）和德国航空航天中心与欧洲航天局共同开展了一项为期60天的人工重力卧床休息研究（AGBRESA）。这项研究的目的是：1）确定每天30分钟的AG在头低位卧床休息期间是否具有保护作用；2）比较每天单次（30分钟）AG与每天多次（6×5分钟）AG（质心处1Gz）对受失重和头低位倾斜卧床休息影响的生理功能的保护作用。AGBRESA研究涉及一套全面的标准和创新技术，以表征广泛生理系统的变化。本文旨在详细概述AGBRESA期间所使用的方法。
