Tulppala M, Björses U M, Stenman U H, Wahlström T, Ylikorkala O
Department I of Obstetrics and Gynecology, University Central Hospital of Helsinki, Finland.
Fertil Steril. 1991 Jul;56(1):41-4. doi: 10.1016/s0015-0282(16)54413-6.
To re-evaluate the occurrence of luteal phase defect (LPD) in habitual abortion and to determine the value of salivary progesterone (P) assay in its diagnosis.
Prospective study on patients with a history of at least three consecutive miscarriages.
Departments I and II of Obstetrics and Gynecology, University Central Hospital of Helsinki, Helsinki, Finland.
Forty-six patients (27 primary and 19 secondary aborters) and 12 healthy control women without a history of abortion.
Eight patients (17.4%, 5 primary and 3 secondary aborters) exhibited a delay of greater than 2 days in endometrial maturation during two consecutive cycles, whereas in 38 patients (82.6%) endometrial maturation corresponded to the actual cycle day. Salivary P showed a distinct ovulatory rise, but no statistically significant differences were evident between patients (with or without LPD) and healthy control women.
An endometrial maturation defect may be a factor in 17.4% of patients with habitual abortion, but this cannot be detected by salivary P assay.
重新评估习惯性流产中黄体期缺陷（LPD）的发生率，并确定唾液孕酮（P）检测在其诊断中的价值。
对有至少连续三次流产病史的患者进行前瞻性研究。
芬兰赫尔辛基大学中心医院妇产科第一和第二科室。
46例患者（27例原发性流产者和19例继发性流产者）以及12名无流产病史的健康对照女性。
8例患者（17.4%，5例原发性流产者和3例继发性流产者）在连续两个周期中子宫内膜成熟延迟超过2天，而38例患者（82.6%）的子宫内膜成熟与实际月经周期天数相符。唾液P显示出明显的排卵后升高，但患者（有或无LPD）与健康对照女性之间无统计学上的显著差异。
子宫内膜成熟缺陷可能是17.4%习惯性流产患者的一个因素，但唾液P检测无法检测到这一点。
