Tulppala M, Julkunen M, Tiitinen A, Stenman U H, Seppälä M
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.
Fertil Steril. 1995 Apr;63(4):792-5. doi: 10.1016/s0015-0282(16)57483-4.
To study serum levels of placental protein 14 (PP14) in relation to endometrial function in women with a history of habitual abortion.
Prospective study.
Departments I and II of Obstetrics and Gynecology, University Central Hospital of Helsinki, Helsinki, Finland.
Fifty patients (26 primary and 24 secondary habitual aborters) and 38 controls without a history of abortion studied during a regular cycle.
Habitual aborters as a whole or when subgrouped into those with normal cycles (n = 40) or with a luteal phase defect (LPD; n = 10) and control women demonstrated a distinct increase in PP14 levels from late follicular to late luteal phases. In the luteal phase, serum PP14 levels were lower in the patients than in the controls (27.2 +/- 3.1 versus 48.5 +/- 10.1 micrograms/L), but the differences in PP14 levels between habitual aborters with or without LPD was not significant (16.3 +/- 4.3 versus 29.9 +/- 3.7 micrograms/L).
Habitual aborters exhibit lower serum PP14 levels in the late luteal phase compared with normal fertile women.
研究有习惯性流产史女性的血清胎盘蛋白14（PP14）水平与子宫内膜功能的关系。
前瞻性研究。
芬兰赫尔辛基大学中心医院妇产科一、二科。
50例患者（26例原发性习惯性流产者和24例继发性习惯性流产者）以及38例无流产史的对照者，在正常月经周期进行研究。
总体习惯性流产者，或分为月经周期正常者（n = 40）及黄体期缺陷者（LPD；n = 10）亚组后，与对照女性相比，从卵泡晚期到黄体晚期PP14水平均有明显升高。在黄体期，患者血清PP14水平低于对照者（27.2±3.1对48.5±10.1微克/升），但有或无LPD的习惯性流产者之间PP14水平差异无统计学意义（16.3±4.3对29.9±3.7微克/升）。
与正常可育女性相比，习惯性流产者在黄体晚期血清PP14水平较低。
