Hughes Joel W, Feldman Michelle E, Beckham Jean C
Department of Psychology, Kent State University. P.O. Box 5190, Kent, OH 44242, USA.
Biol Psychol. 2006 Mar;71(3):296-302. doi: 10.1016/j.biopsycho.2005.06.002. Epub 2005 Jul 11.
The relationship between posttraumatic stress disorder (PTSD) and parasympathetic nervous system (PNS) functioning was investigated using baroreflex sensitivity (BRS). We hypothesized that individuals with PTSD would exhibit lower BRS than those without PTSD.
Participants were 80 PTSD patients and 50 controls aged 18-68 years. All participants were smokers, many were veterans (55%), and 60 were women. Beat-to-beat BP was collected during a 5-min baseline rest periods from which estimates of BRS were derived using the sequence method.
Women with PTSD exhibited lower BRS (M = 10.5, S.D. = 5.1) than women without PTSD (M = 14.6, S.D. = 10.7). For men, PTSD diagnosis was not associated with BRS, p > .05.
Among women, PTSD was associated with reduced PNS functioning. Men with PTSD did not have attenuated BRS, which may be due to sample characteristics, such as age and combat veteran status. Reduced PNS activity may predispose women with PTSD to poorer cardiovascular health.
使用压力反射敏感性（BRS）研究创伤后应激障碍（PTSD）与副交感神经系统（PNS）功能之间的关系。我们假设患有PTSD的个体比未患PTSD的个体表现出更低的BRS。
参与者为80名年龄在18 - 68岁之间的PTSD患者和50名对照者。所有参与者均为吸烟者，许多是退伍军人（55%），且有60名女性。在5分钟的基线休息期收集逐搏血压，使用序列法从中得出BRS估计值。
患有PTSD的女性表现出比未患PTSD的女性更低的BRS（均值 = 10.5，标准差 = 5.1）（未患PTSD的女性均值 = 14.6，标准差 = 10.7）。对于男性，PTSD诊断与BRS无关，p > 0.05。
在女性中，PTSD与PNS功能降低有关。患有PTSD的男性没有BRS减弱的情况，这可能归因于样本特征，如年龄和退伍军人身份。PNS活动降低可能使患有PTSD的女性更容易出现较差的心血管健康状况。
