Tojo Kana, Tokuda Takahiko, Hoshii Yoshinobu, Fu Xiaoying, Higuchi Keiichi, Matsui Takane, Kametani Fuyuki, Ikeda Shu-Ichi
Third Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Amyloid. 2005 Jun;12(2):103-8. doi: 10.1080/13506120500107097.
Experimental mouse AA amyloidosis can be transmissible by dietary ingestion of amyloid fibrils and it is well known that AA amyloidosis occasionally develops in aged cattle. Bovine liver and intestine have conventionally been used in Oriental foods, and the incidence of visceral AA amyloidosis in slaughtered cattle was evaluated. Renal tissues from 302 aged cattle older than 4 years were obtained from a local abattoir. Amyloid deposition was microscopically examined and amyloid protein was immunochemically determined. Renal amyloid deposition was seen in 15 out of 302 cattle with no previous history of diseas, an incidence of 5.0%. Amyloid protein in these cattle was AA and they had pathological findings in their visceral organs on gross examination. The incidence of visceral AA amyloidosis in slaughtered cattle in this study was disturbingly high compared with those (0.4-2.7%) previously reported from Japan and other foreign countries. AA amyloidosis is a life-threatening complication in patients with chronic inflammatory diseases and these patients at risk should avoid ingesting food that may possibly contain AA amyloid fibrils. More detailed information on cattle amyloidosis is required to guarantee the safety of our food.
实验性小鼠AA淀粉样变性可通过饮食摄入淀粉样纤维进行传播，并且众所周知，AA淀粉样变性偶尔会在老龄牛中发生。牛肝和牛肠传统上用于东方食品，因此对屠宰牛内脏AA淀粉样变性的发病率进行了评估。从当地一家屠宰场获取了302头4岁以上老龄牛的肾脏组织。对淀粉样沉积进行了显微镜检查，并通过免疫化学方法测定了淀粉样蛋白。在302头牛中，有15头之前没有疾病史的牛出现了肾脏淀粉样沉积，发病率为5.0%。这些牛体内的淀粉样蛋白为AA型，并且在大体检查时其内脏器官有病理表现。与日本和其他国家之前报道的发病率（0.4 - 2.7%）相比，本研究中屠宰牛内脏AA淀粉样变性的发病率高得惊人。AA淀粉样变性是慢性炎症性疾病患者的一种危及生命的并发症，这些有风险的患者应避免摄入可能含有AA淀粉样纤维的食物。为确保我们食物的安全，需要更多关于牛淀粉样变性的详细信息。
