肝细胞癌的生长速率：通过系列计算机断层扫描或磁共振成像进行评估

Growth rate of hepatocellular carcinoma: evaluation with serial computed tomography or magnetic resonance imaging.

作者信息

Taouli Bachir, Goh Jeffrey S K, Lu Ying, Qayyum Aliya, Yeh Benjamin M, Merriman Raphael B, Coakley Fergus V

机构信息

Department of Radiology, University of California, San Francisco, CA, USA.

出版信息

J Comput Assist Tomogr. 2005 Jul-Aug;29(4):425-9. doi: 10.1097/01.rct.0000164036.85327.05.

DOI:10.1097/01.rct.0000164036.85327.05

PMID:16012295

Abstract

OBJECTIVE

To evaluate the growth rate of untreated hepatocellular carcinoma (HCC) by calculating tumor volume doubling time (TVDT) on serial computed tomography (CT) or magnetic resonance imaging (MRI) and to predict TVDT based on initial tumor size.

METHODS

Sixteen untreated HCCs in 11 patients with cirrhosis who underwent serial CT or MRI at our institution were retrospectively identified. Two independent readers recorded bidimensional measurements for all tumors, which were used to determine tumor volume (TV). Growth rate was expressed as TVDT. A mathematic model was used to predict TVDT based on baseline tumor size.

RESULTS

Mean baseline and follow-up TVs were 10.5 cm3 (range: 0.7-243.6 cm3) and 22.0 cm3 (range: 2.5-870.8 cm3), respectively. Mean duration of follow-up was 176 days (range: 76-472 days). Mean TVDT was 127 days (95% confidence interval: 80, 203; range: 17.5-541.4 days). Expected TVDT could be expressed as TVDT = 114 x (baseline volume)0.14 (P < 0.002).

CONCLUSION

The results of this study suggest a preferred interval follow-up of approximately 4.5 months (127 days) for HCC screening. Small HCCs show a tendency toward faster growth and may require shorter follow-up to demonstrate progression.

摘要

目的

通过计算连续计算机断层扫描（CT）或磁共振成像（MRI）上的肿瘤体积倍增时间（TVDT）来评估未经治疗的肝细胞癌（HCC）的生长速度，并基于初始肿瘤大小预测TVDT。

方法

回顾性纳入在本机构接受连续CT或MRI检查的11例肝硬化患者中的16个未经治疗的HCC。两名独立的阅片者记录所有肿瘤的二维测量值，用于确定肿瘤体积（TV）。生长速度用TVDT表示.使用数学模型根据基线肿瘤大小预测TVDT。

结果

平均基线和随访时的TV分别为10.5cm³（范围：0.7 - 243.6cm³）和22.0cm³（范围：2.5 - 870.8cm³）.平均随访时间为176天（范围：76 - 472天）。平均TVDT为127天（95%置信区间：80, 203；范围：17.5 - 541.4天）。预期TVDT可表示为TVDT = 114×（基线体积）^0.14（P < 0.002）。