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肿瘤加速生长:详述肝细胞癌的侵袭性病程

Tumor Growth in Overdrive: Detailing an Aggressive Course of Hepatocellular Carcinoma.

作者信息

Singh Simardeep, Delungahawatta Thilini, Wolff Marcos, Haas Christopher J

机构信息

MedStar Union Memorial Hospital, Baltimore, MD, USA.

MedStar Franklin Square Medical Center, Baltimore, MD, USA.

出版信息

Case Reports Hepatol. 2024 Jun 15;2024:4950398. doi: 10.1155/2024/4950398. eCollection 2024.

DOI:10.1155/2024/4950398
PMID:38974801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11226333/
Abstract

Hepatocellular carcinoma ranks as the third leading cause of cancer-related mortality globally. We present a case of a rapidly progressive hepatocellular carcinoma in an 81-year-old female with metabolic abnormalities. The patient initially presented with non-specific signs and symptoms and was managed for sepsis of suspected urinary source. Unresolving laboratory markers led to repeat abdominal imaging demonstrating new hepatic lesions within six days. Biopsy confirmed moderately differentiated hepatocellular carcinoma. The patient received conservative inpatient treatment with recommendation for nutritional and performance status optimization prior to oncologic therapies, however continued to decline and passed away three months later.

摘要

肝细胞癌是全球癌症相关死亡的第三大主要原因。我们报告一例81岁患有代谢异常的女性快速进展性肝细胞癌病例。患者最初表现为非特异性体征和症状,因疑似泌尿道来源的败血症接受治疗。实验室指标持续异常导致在六天内重复进行腹部影像学检查,发现新的肝脏病变。活检证实为中度分化肝细胞癌。患者接受了保守的住院治疗,并建议在进行肿瘤治疗前优化营养和身体状况,但病情仍持续恶化,三个月后去世。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a8a/11226333/1ea351d684c5/CRIHEP2024-4950398.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a8a/11226333/39ccad743836/CRIHEP2024-4950398.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a8a/11226333/1ea351d684c5/CRIHEP2024-4950398.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a8a/11226333/39ccad743836/CRIHEP2024-4950398.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a8a/11226333/1ea351d684c5/CRIHEP2024-4950398.002.jpg

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本文引用的文献

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Prognostic Scores and Survival Rates by Etiology of Hepatocellular Carcinoma: A Review.肝细胞癌病因的预后评分与生存率:综述
J Clin Med Res. 2023 Apr;15(4):200-207. doi: 10.14740/jocmr4902. Epub 2023 Apr 28.
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The latest global burden of liver cancer: A past and present threat.最新的全球肝癌负担:过去与现在的威胁。
Clin Mol Hepatol. 2023 Apr;29(2):355-357. doi: 10.3350/cmh.2023.0070. Epub 2023 Mar 9.
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PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing.
PRPF8 通过调节纤维连接蛋白 1 的剪接来增加肝癌的侵袭性,该过程涉及 FAK/AKT 通路。
Exp Mol Med. 2023 Jan;55(1):132-142. doi: 10.1038/s12276-022-00917-7. Epub 2023 Jan 6.
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Pathogenesis and Current Treatment Strategies of Hepatocellular Carcinoma.肝细胞癌的发病机制与当前治疗策略
Biomedicines. 2022 Dec 9;10(12):3202. doi: 10.3390/biomedicines10123202.
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Splicing factor SF3B1 is overexpressed and implicated in the aggressiveness and survival of hepatocellular carcinoma.剪接因子 SF3B1 过表达并与肝细胞癌的侵袭性和生存能力有关。
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Gut. 2021 Feb;70(2):401-407. doi: 10.1136/gutjnl-2020-321040. Epub 2020 May 12.
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Hepatocellular Carcinoma Demonstrates Heterogeneous Growth Patterns in a Multicenter Cohort of Patients With Cirrhosis.肝细胞癌在肝硬化多中心队列患者中表现出异质性生长模式。
Hepatology. 2020 Nov;72(5):1654-1665. doi: 10.1002/hep.31159. Epub 2020 Oct 25.
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Qidong: a crucible for studies on liver cancer etiology and prevention.启东:肝癌病因学与预防研究的“熔炉”
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BMC Endocr Disord. 2019 Apr 25;19(1):40. doi: 10.1186/s12902-019-0366-3.
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Metabolic syndrome relates to high risk in hepatocellular carcinoma: a meta-analysis.代谢综合征与肝细胞癌的高风险相关:一项荟萃分析。
Discov Med. 2018 Nov;26(144):185-196.