Raipulis J, Toma M M, Semjonovs P
Institute of Microbiology and Biotechnology, University of Latvia, Kronvalda boulv. 4, Riga LV-1586, Latvia.
Int J Food Microbiol. 2005 Jul 25;102(3):343-7. doi: 10.1016/j.ijfoodmicro.2004.11.029.
Antigenotoxic activity of probiotic bacteria against furazolidone was studied using the short-term bacterial assay SOS chromotest, with Escherichia coli PQ37 as the test organism. The supernatants from probiotic and furazolidone co-incubation exhibited rather strong suppression on SOS induction produced by furazolidone on E. coli PQ 37 (sfiA: lacZ). Genotoxicity inhibition was found for all strains of the examined bacteria belonging to three genera. The highest genotoxicity inhibition was detected for Bifidobacterium lactis Bb-12 (92.0%) and for Lactobacillus acidophilus T20 (81.9%).
采用短期细菌试验SOS显色试验，以大肠杆菌PQ37作为受试生物，研究了益生菌对呋喃唑酮的抗遗传毒性活性。益生菌与呋喃唑酮共孵育的上清液对呋喃唑酮诱导大肠杆菌PQ37（sfiA:lacZ）产生的SOS表现出相当强的抑制作用。在所检测的属于三个属的所有细菌菌株中均发现了遗传毒性抑制作用。乳酸双歧杆菌Bb-12（92.0%）和嗜酸乳杆菌T20（81.9%）的遗传毒性抑制作用最强。
