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[小儿麻痹后遗症患者的肌肉骨骼症状]

[Musculoskeletal symptoms in patients with post-polio syndrome].

作者信息

Balzien B, Hofner B, Harlander-Weikert E, Frommelt P, Bork H, Forst R, Fujak A

机构信息

Klinik für Orthopädie, Unfallchirurgie und Sporttraumatologie Köln-Merheim, Kliniken der Stadt Köln gGmbH.

Institut für Medizininformatik, Biometrie und Epidemiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen.

出版信息

Z Orthop Unfall. 2014 Jun;152(3):241-6. doi: 10.1055/s-0034-1368531. Epub 2014 Jun 24.

Abstract

BACKGROUND

The prevalence of the post-polio syndrome (PPS) is in estimated 50 % of persons with established poliomyelitis with a subsequently stable phase of at least 15 years. The basic mechanism is a loss of motoneuron cells in the spinal cord resulting in muscle weakness and fatigue. In addition pain, cold intolerance and a loss of stamina are frequently reported. There are few studies focusing on the orthopaedic symptoms in the PPS. This study should support the health-care professionals to the address the needs of PPS patients.

METHODS

A questionnaire was developed to collect data on patients who have been diagnosed by a neurologist as fulfilling the criteria of a PPS. It consists of two parts. In the first part, general patient data are collected. In the second part, details of health, pain, and activities of daily living are collected at two points in time: the time of the stable phase immediately after the acute phase of the disease and the phase after the PPS diagnosis. The questionnaires were sent to patients with a diagnosis of PPS. A total of 124 questionnaires were analysed (male: 45, female: 79). Parts of the data were used to calculate a score. It was hypothesised that the score would demonstrate a higher load of orthopaedic symptoms in the PPS phase.

RESULTS

The results show that the phase after poliomyelitis (stable phase vs. PPS phase) was associated with significantly different sum score relating to the orthopaedic impairments. The score in the stable phase is on average 18.6 units lower than that in the post-PPS diagnosis phase (p < 0.001). The hypothesis that in the PPS phase the load of orthopaedic symptoms is increased is confirmed by our data. The "loss of functioning in the upper extremity" is also significantly associated with the score (p = 0.004).

CONCLUSIONS

At the time the survey was taken, patients reveal a high level of musculoskeletal impairments and disabilities after PPS than during the stable phase with regard to general health as well as pain status and performance of daily activities. Age has no significant impact. Many of the patients are severely limited, especially with regard to activities such as walking, climbing stairs, and performing simple household tasks. Since there is no causal therapy for the underlying degeneration of the anterior horn cell pools, treatment is focused on the compensation of the functional limitations.

摘要

背景

小儿麻痹后遗症(PPS)的患病率估计在既往患小儿麻痹症且随后有至少15年稳定期的人群中为50%。其基本机制是脊髓运动神经元细胞丧失,导致肌肉无力和疲劳。此外,疼痛、不耐寒和耐力下降也屡有报道。很少有研究关注PPS中的骨科症状。本研究旨在帮助医疗保健专业人员满足PPS患者的需求。

方法

设计了一份问卷,收集经神经科医生诊断符合PPS标准的患者的数据。问卷由两部分组成。第一部分收集患者的一般数据。第二部分在两个时间点收集健康、疼痛和日常生活活动的详细信息:疾病急性期后的稳定期以及PPS诊断后的阶段。问卷发送给诊断为PPS的患者。共分析了124份问卷(男性:45份,女性:79份)。部分数据用于计算得分。假设该得分将显示PPS阶段骨科症状的负荷更高。

结果

结果表明,小儿麻痹症后的阶段(稳定期与PPS期)与骨科损伤的总分显著不同有关。稳定期的得分平均比PPS诊断后阶段低18.6分(p < 0.001)。我们的数据证实了PPS阶段骨科症状负荷增加的假设。“上肢功能丧失”也与得分显著相关(p = 0.004)。

结论

在进行调查时,与稳定期相比,PPS患者在一般健康状况、疼痛状态和日常活动表现方面显示出更高水平的肌肉骨骼损伤和残疾。年龄没有显著影响。许多患者受到严重限制,尤其是在行走、爬楼梯和执行简单家务等活动方面。由于对于前角细胞池的潜在退化没有因果治疗方法,治疗重点在于补偿功能限制。

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