Rubio-Texeira Marta
Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
FEMS Yeast Res. 2005 Dec;5(12):1115-28. doi: 10.1016/j.femsyr.2005.05.003. Epub 2005 Jul 1.
Despite their close phylogenetic relationship, Kluyveromyces lactis and Saccharomyces cerevisiae have adapted their carbon utilization systems to different environments. Although they share identities in the arrangement, sequence and functionality of their GAL gene set, both yeasts have evolved important differences in the GAL genetic switch in accordance to their relative preference for the utilization of galactose as a carbon source. This review provides a comparative overview of the GAL-specific regulatory network in S. cerevisiae and K. lactis, discusses the latest models proposed to explain the transduction of the galactose signal, and describes some of the particularities that both microorganisms display in their regulatory response to different carbon sources. Emphasis is placed on the potential for improved strategies in biotechnological applications using yeasts.
尽管乳酸克鲁维酵母和酿酒酵母在系统发育上关系密切，但它们已使其碳利用系统适应了不同的环境。虽然它们在GAL基因集的排列、序列和功能方面具有相同之处，但根据它们对利用半乳糖作为碳源的相对偏好，这两种酵母在GAL基因开关方面已进化出重要差异。本综述对酿酒酵母和乳酸克鲁维酵母中GAL特异性调控网络进行了比较概述，讨论了为解释半乳糖信号转导而提出的最新模型，并描述了这两种微生物在对不同碳源的调控反应中表现出的一些特性。重点在于利用酵母在生物技术应用中改进策略的潜力。
