Hermann Christian, Westergaard Tine, Pedersen Bo V, Wohlfahrt Jan, Høst Arne, Melbye Mads
Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen, Denmark.
Am J Epidemiol. 2005 Aug 15;162(4):345-50. doi: 10.1093/aje/kwi212. Epub 2005 Jul 13.
In a study of 2,978 Danish children aged 5 years from two suburban counties of Copenhagen, carried out in 1998, the authors compared risk factor profiles for wheeze and recurrent cough without wheeze by using polytomous logistic regression to clarify whether the two conditions are likely to have the same etiology. Data were obtained 1) by a mailed parental questionnaire (International Study of Asthma and Allergies in Childhood questions and supplementary questions on cough, sociodemography, perinatal factors, and environmental exposure); 2) through general practitioners (familial allergic disease); and 3) from the National Medical Birth Register (birth weight). Wheeze (WH) was defined as more than one episode of wheeze within the last 12 months (irrespective of cough status) and recurrent cough without WH (RC) as cough occurring outside colds and usually lasting for periods of more than 1 week in children with no more than one attack of wheeze within the last 12 months. Risk factors for comparison were selected as those that, after repeated stepwise logistic regression, remained significant for children with WH or RC. Significant differences were found for gender (p = 0.003), gestational age (p = 0.0002), maternal history of asthma (p = 0.0008), and standard of housing condition (p = 0.04)-all risk factors for WH but not RC. Results may suggest that the two conditions have different etiologies.
1998年，作者对哥本哈根两个郊区县的2978名5岁丹麦儿童进行了一项研究，通过多分类逻辑回归比较了喘息和无喘息的反复咳嗽的危险因素概况，以阐明这两种情况是否可能具有相同的病因。数据通过以下方式获得：1）邮寄家长问卷（儿童哮喘和过敏国际研究的问题以及关于咳嗽、社会人口统计学、围产期因素和环境暴露的补充问题）；2）通过全科医生（家族性过敏性疾病）；3）从国家医疗出生登记处（出生体重）。喘息（WH）定义为过去12个月内有不止一次喘息发作（无论咳嗽状况如何），无喘息的反复咳嗽（RC）定义为在感冒以外发生的咳嗽，对于过去12个月内喘息发作不超过一次的儿童，咳嗽通常持续超过1周。作为比较的危险因素是那些在反复逐步逻辑回归后，对患有WH或RC的儿童仍具有显著性的因素。发现性别（p = 0.003）、胎龄（p = 0.0002）、母亲哮喘病史（p = 0.0008）和住房条件标准（p = 0.04）存在显著差异——所有这些都是WH的危险因素，但不是RC的危险因素。结果可能表明这两种情况有不同的病因。
