Linneberg Allan, Simonsen Jacob B, Petersen Janne, Stensballe Lone G, Benn Christine S
Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.
J Allergy Clin Immunol. 2006 Jan;117(1):184-9. doi: 10.1016/j.jaci.2005.09.042. Epub 2005 Dec 2.
Atopic dermatitis (AD) often develops in infancy as the first manifestation of the atopic phenotype. Wheezing is also common in infancy, but it is less clear whether infant wheezing should be considered as an atopic phenotype. If infant wheeze and AD share a common aetiology, this would indicate that infant wheezing is an atopic phenotype.
To investigate whether potential risk factors for infant wheeze and AD have similar effects on these 2 phenotypes, indicating a common etiology.
A total of 34.793 mother-child pairs enrolled in the Danish National Birth Cohort were followed prospectively. Information on wheezing episodes, AD, and prenatal, perinatal, and postnatal risk factors was collected by interview at 12 and 30 weeks of gestation, at 6 and 18 months of age, and by linkage to the Danish Medical Birth Register. Data were analyzed by binary and polytomous logistic regression models.
The following variables had significantly differential effects on infant wheezing and AD: parental hay fever, parental asthma, parental AD, sex, maternal age, maternal occupation, smoking during pregnancy, season of birth, birth weight, gestational age, head circumference, breast-feeding, number of older siblings, day care attendance, and pets in the home.
The majority of risk factors had differential effects on infant wheeze and AD indicative of a different etiology. Infant wheezing does not seem to be etiologically linked to the epidemic of atopic disease, and infant wheezing should not be used as an indicator of the atopic phenotype.
特应性皮炎（AD）常在婴儿期作为特应性表型的首发表现出现。喘息在婴儿期也很常见，但婴儿喘息是否应被视为特应性表型尚不清楚。如果婴儿喘息和AD有共同的病因，这将表明婴儿喘息是一种特应性表型。
调查婴儿喘息和AD的潜在风险因素对这两种表型是否有相似影响，以表明存在共同病因。
对丹麦国家出生队列中登记的34793对母婴进行前瞻性随访。通过在妊娠12周和30周、6个月和18个月时进行访谈，并与丹麦医学出生登记处建立联系，收集有关喘息发作、AD以及产前、围产期和产后风险因素的信息。数据通过二元和多分类逻辑回归模型进行分析。
以下变量对婴儿喘息和AD有显著不同的影响：父母过敏性鼻炎、父母哮喘、父母AD、性别、母亲年龄、母亲职业、孕期吸烟、出生季节、出生体重、胎龄、头围、母乳喂养、哥哥姐姐数量、日托情况以及家中宠物。
大多数风险因素对婴儿喘息和AD有不同影响，表明病因不同。婴儿喘息似乎在病因上与特应性疾病的流行无关，婴儿喘息不应被用作特应性表型的指标。
