Fogg Mark H, Carville Angela, Cameron Jennifer, Quink Carol, Wang Fred
Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
J Virol. 2005 Aug;79(15):10069-72. doi: 10.1128/JVI.79.15.10069-10072.2005.
The recent discovery of an Epstein-Barr virus (EBV)-related lymphocryptovirus (LCV) naturally infecting common marmosets demonstrated that gamma-1 herpesviruses are not limited to human and Old World nonhuman primate hosts. We developed serologic assays to detect serum antibodies against lytic- and latent-infection marmoset LCV antigens in order to perform the first seroepidemiologic study of LCV infection in New World primates. In three different domestic colonies and in animals recently captured from the wild, we found that the seroprevalence of marmoset LCV infection was not as ubiquitous as with EBV or Old World LCV. These biologic differences in LCV infection of New World versus human and Old World primate hosts correlate with the evolution of the LCV viral gene repertoire.
最近发现一种与爱泼斯坦-巴尔病毒（EBV）相关的淋巴隐病毒（LCV）可自然感染普通狨猴，这表明γ-1疱疹病毒并不局限于人类和旧世界非人灵长类宿主。我们开发了血清学检测方法，以检测针对裂解性和潜伏性感染的狨猴LCV抗原的血清抗体，从而对新大陆灵长类动物中的LCV感染进行首次血清流行病学研究。在三个不同的家养群体以及最近从野外捕获的动物中，我们发现狨猴LCV感染的血清阳性率并不像EBV或旧世界LCV那样普遍存在。新大陆灵长类宿主与人类和旧世界灵长类宿主在LCV感染方面的这些生物学差异与LCV病毒基因库的进化相关。
