一种来自狨猴淋巴瘤的与爱泼斯坦-巴尔病毒相关的疱疹病毒。
An Epstein-Barr-related herpesvirus from marmoset lymphomas.
作者信息
Cho Y, Ramer J, Rivailler P, Quink C, Garber R L, Beier D R, Wang F
机构信息
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1224-9. doi: 10.1073/pnas.98.3.1224.
Epstein-Barr virus (EBV) is implicated in the development of human B cell lymphomas and carcinomas. Although related oncogenic herpesviruses were believed to be endemic only in Old World primate species, we now find these viruses to be endemic in New World primates. We have isolated a transforming, EBV-related virus from spontaneous B cell lymphomas of common marmosets (Callithrix jacchus). Sequencing of two-thirds of the genome reveals considerable divergence from the genomes of EBV and Old World primate EBV-related viruses, including differences in genes important for virus-induced cell growth transformation and pathogenesis. DNA related to the C. jacchus herpesvirus is frequently detected in squirrel monkey peripheral blood lymphocytes, indicating that persistent infection with EBV-related viruses is prevalent in both New World primate families. Understanding how these more divergent EBV-related viruses achieve similar biologic outcomes in their natural host is likely to provide important insights into EBV infection, B cell growth transformation, and oncogenesis.
爱泼斯坦-巴尔病毒（EBV）与人类B细胞淋巴瘤和癌的发生有关。尽管相关致癌性疱疹病毒曾被认为仅在旧世界灵长类物种中流行，但我们现在发现这些病毒在新世界灵长类动物中也有流行。我们从普通狨猴（Callithrix jacchus）的自发性B细胞淋巴瘤中分离出一种具有转化能力的、与EBV相关的病毒。对该病毒基因组三分之二的测序显示，它与EBV及旧世界灵长类EBV相关病毒的基因组存在相当大的差异，包括在对病毒诱导的细胞生长转化和发病机制至关重要的基因方面的差异。在松鼠猴外周血淋巴细胞中经常检测到与普通狨猴疱疹病毒相关的DNA，这表明在两个新世界灵长类动物家族中，与EBV相关病毒的持续感染都很普遍。了解这些差异更大的与EBV相关的病毒如何在其天然宿主中实现相似的生物学结果，可能会为EBV感染、B细胞生长转化和肿瘤发生提供重要的见解。
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