Ehlers Bernhard, Ochs Andreas, Leendertz Fabian, Goltz Michael, Boesch Christophe, Mätz-Rensing Kerstin
Robert Koch-Institut, D-13353, Germany.
J Virol. 2003 Oct;77(19):10695-9. doi: 10.1128/jvi.77.19.10695-10699.2003.
Thirty different lymphocryptoviruses (LCV), 26 of them novel, were detected in primates by a panherpesvirus PCR assay. Nineteen LCV from chimpanzees, bonobos, gorillas, and other Old World primates were closely related to Epstein-Barr virus (EBV), the type species of the genus lymphocryptovirus. Seven LCV originating from New World primates were related to callitrichine herpesvirus 3 (CalHV-3), the first recognized New World LCV. Importantly, a second LCV from gorillas and three LCV from orangutans and gibbons were only distantly related to EBV and CalHV-3. They were tentatively assigned to a novel genogroup of Old World primate LCV. The work described in the paper may also help identify an as yet unknown human LCV.
通过全疱疹病毒聚合酶链反应检测法，在灵长类动物中检测到30种不同的淋巴细胞隐病毒（LCV），其中26种是新发现的。来自黑猩猩、倭黑猩猩、大猩猩和其他旧世界灵长类动物的19种LCV与淋巴细胞隐病毒属的模式种——爱泼斯坦-巴尔病毒（EBV）密切相关。来自新世界灵长类动物的7种LCV与最早被识别的新世界LCV——绢毛猴疱疹病毒3型（CalHV-3）相关。重要的是，来自大猩猩的第二种LCV以及来自猩猩和长臂猿的三种LCV与EBV和CalHV-3只有远缘关系。它们被初步归为旧世界灵长类动物LCV的一个新基因组。该论文中描述的研究工作也可能有助于识别一种尚未知晓的人类LCV。
