Choi M J, Maibach H I
Department of Dermatology, University of California, School of Medicine, San Francisco, California 94143-0989, USA.
Skin Pharmacol Physiol. 2005 Sep-Oct;18(5):209-19. doi: 10.1159/000086666. Epub 2005 Jul 5.
The skin acts as a major target as well as a principle barrier for topical/transdermal (TT) drug delivery. The stratum corneum plays a crucial role in barrier function for TT drug delivery. Despite major research and development efforts in TT systems and the advantages of these routes, low stratum corneum permeability limits the usefulness of topical drug delivery. To overcome this, methods have been assessed to increase permeation. One controversial method is the use of vesicular systems, such as liposomes and niosomes, whose effectiveness depends on their physicochemical properties. This review focuses on the effect of liposomes and niosomes on enhancing drug penetration, and defines the effect of composition, size and type of the vesicular system on TT delivery.
皮肤既是局部/透皮给药的主要靶点，也是主要屏障。角质层在透皮给药的屏障功能中起着关键作用。尽管在透皮给药系统方面进行了大量研发工作，且这些给药途径具有诸多优势，但角质层低渗透性限制了局部给药的效用。为克服这一问题，人们评估了多种增加渗透的方法。一种有争议的方法是使用囊泡系统，如脂质体和非离子表面活性剂囊泡，其有效性取决于它们的物理化学性质。本综述重点关注脂质体和非离子表面活性剂囊泡对增强药物渗透的作用，并确定囊泡系统的组成、大小和类型对透皮给药的影响。
